Calcium bridges built by mitochondria-associated endoplasmic reticulum membranes: potential targets for neural repair in neurological diseases.

IF 5.9 2区 医学 Q2 CELL BIOLOGY
Neural Regeneration Research Pub Date : 2025-12-01 Epub Date: 2024-11-13 DOI:10.4103/NRR.NRR-D-24-00630
Yichen Peng, Li Zhou, Yaju Jin, Danli Wu, Na Chen, Chengcai Zhang, Hongpeng Liu, Chunlan Li, Rong Ning, Xichen Yang, Qiuyue Mao, Jiaxin Liu, Pengyue Zhang
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引用次数: 0

Abstract

The exchange of information and materials between organelles plays a crucial role in regulating cellular physiological functions and metabolic levels. Mitochondria-associated endoplasmic reticulum membranes serve as physical contact channels between the endoplasmic reticulum membrane and the mitochondrial outer membrane, formed by various proteins and protein complexes. This microstructural domain mediates several specialized functions, including calcium (Ca 2+ ) signaling, autophagy, mitochondrial morphology, oxidative stress response, and apoptosis. Notably, the dysregulation of Ca 2+ signaling mediated by mitochondria-associated endoplasmic reticulum membranes is a critical factor in the pathogenesis of neurological diseases. Certain proteins or protein complexes within these membranes directly or indirectly regulate the distance between the endoplasmic reticulum and mitochondria, as well as the transduction of Ca 2+ signaling. Conversely, Ca 2+ signaling mediated by mitochondria-associated endoplasmic reticulum membranes influences other mitochondria-associated endoplasmic reticulum membrane-associated functions. These functions can vary significantly across different neurological diseases-such as ischemic stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease-and their respective stages of progression. Targeted modulation of these disease-related pathways and functional proteins can enhance neurological function and promote the regeneration and repair of damaged neurons. Therefore, mitochondria-associated endoplasmic reticulum membranes-mediated Ca 2+ signaling plays a pivotal role in the pathological progression of neurological diseases and represents a significant potential therapeutic target. This review focuses on the effects of protein complexes in mitochondria-associated endoplasmic reticulum membranes and the distinct roles of mitochondria-associated endoplasmic reticulum membranes-mediated Ca 2+ signaling in neurological diseases, specifically highlighting the early protective effects and neuronal damage that can result from prolonged mitochondrial Ca 2+ overload or deficiency. This article provides a comprehensive analysis of the various mechanisms of Ca 2+ signaling mediated by mitochondria-associated endoplasmic reticulum membranes in neurological diseases, contributing to the exploration of potential therapeutic targets for promoting neuroprotection and nerve repair.

线粒体相关内质网膜构建的钙桥:神经系统疾病中神经修复的潜在目标。
细胞器之间的信息和物质交换在调节细胞生理功能和代谢水平方面起着至关重要的作用。线粒体相关内质网膜是内质网膜和线粒体外膜之间的物理接触通道,由各种蛋白质和蛋白质复合物形成。这一微结构域介导了多种特殊功能,包括钙(Ca2+)信号传导、自噬、线粒体形态、氧化应激反应和细胞凋亡。值得注意的是,线粒体相关内质网膜介导的 Ca2+ 信号传导失调是神经系统疾病发病机制中的一个关键因素。这些膜内的某些蛋白质或蛋白质复合物直接或间接地调节内质网和线粒体之间的距离,以及 Ca2+ 信号的传导。相反,由线粒体相关内质网膜介导的 Ca2+ 信号转导会影响线粒体相关内质网膜的其他相关功能。这些功能在不同的神经系统疾病(如缺血性中风、创伤性脑损伤、阿尔茨海默病、帕金森病、肌萎缩性脊髓侧索硬化症和亨廷顿氏病)及其各自的进展阶段会有很大不同。对这些疾病相关途径和功能蛋白进行靶向调节,可以增强神经功能,促进受损神经元的再生和修复。因此,线粒体相关内质网膜介导的 Ca2+ 信号传导在神经系统疾病的病理进展中起着关键作用,是一个重要的潜在治疗靶点。这篇综述侧重于线粒体相关内质网膜蛋白复合物的作用以及线粒体相关内质网膜介导的 Ca2+ 信号在神经系统疾病中的独特作用,特别强调了线粒体 Ca2+ 长期超载或缺乏可能产生的早期保护作用和神经元损伤。本文全面分析了神经系统疾病中线粒体相关内质网膜介导的 Ca2+ 信号转导的各种机制,有助于探索促进神经保护和神经修复的潜在治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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