Trends of diagnostic adverse events in hospital deaths: longitudinal analyses of four retrospective record review studies.

IF 2.2 Q2 MEDICINE, GENERAL & INTERNAL
Diagnosis Pub Date : 2024-11-27 DOI:10.1515/dx-2024-0117
Jacky Hooftman, Laura Zwaan, Jonne J Sikkens, Bo Schouten, Martine C de Bruijne, Cordula Wagner
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引用次数: 0

Abstract

Objectives: To investigate longitudinal trends in the incidence, preventability, and causes of DAEs (diagnostic adverse events) between 2008 and 2019 and compare DAEs to other AE (adverse event) types.

Methods: This study investigated longitudinal trends of DAEs using combined data from four large Dutch AE record review studies. The original four AE studies included 100-150 randomly selected records of deceased patients from around 20 hospitals in each study, resulting in a total of 10,943 patient records. Nurse reviewers indicated cases with potential AEs using a list of triggers. Subsequently, experienced physician reviewers systematically judged the occurrence of AEs, the clinical process in which these AEs occurred, and the preventability and causes.

Results: The incidences of DAEs, potentially preventable DAEs and potentially preventable DAE-related deaths initially declined between 2008 and 2012 (2.3 vs. 1.2; OR=0.52, 95 % CI: 0.32 to 0.83), after which they stabilized up to 2019. These trends were largely the same for other AE types, although compared to DAEs, the incidence of other AE types increased between 2016 (DAE: 1.0, other AE types: 8.5) and 2019 (DAE: 0.8, other AE types: 13.0; rate ratio=1.88, 95 % CI: 1.12 to 2.13). Furthermore, DAEs were more preventable (p<0.001) and were associated with more potentially preventable deaths (p=0.016) than other AE types. In addition, DAEs had more and different underlying causes than other AE types (p<0.001). The DAE causes remained stable over time, except for patient-related factors, which increased between 2016 and 2019 (29.5 and 58.6 % respectively, OR=3.40, 95 % CI: 1.20 to 9.66).

Conclusions: After initial improvements of DAE incidences in 2012, no further improvement was observed in Dutch hospitals in the last decade. Similar trends were observed for other AEs. The high rate of preventability of DAEs suggest a high potential for improvement, that should be further investigated.

医院死亡病例中诊断性不良事件的趋势:四项回顾性记录研究的纵向分析。
目的调查 2008 年至 2019 年间 DAEs(诊断性不良事件)的发生率、可预防性和原因的纵向趋势,并将 DAEs 与其他 AE(不良事件)类型进行比较:本研究利用荷兰四项大型 AE 记录审查研究的综合数据,对 DAE 的纵向趋势进行了调查。最初的四项 AE 研究包括从每项研究的约 20 家医院中随机抽取的 100-150 份死亡患者记录,共计 10943 份患者记录。护士审查员使用触发器列表指出可能发生 AE 的病例。随后,由经验丰富的医生审阅员系统地判断AE的发生情况、这些AE发生的临床过程以及可预防性和原因:2008年至2012年间,DAE、潜在可预防DAE和潜在可预防DAE相关死亡的发生率开始下降(2.3 vs. 1.2; OR=0.52, 95 % CI: 0.32 to 0.83),之后稳定至2019年。这些趋势与其他 AE 类型大致相同,不过与 DAE 相比,其他 AE 类型的发生率在 2016 年(DAE:1.0,其他 AE 类型:8.5)至 2019 年(DAE:0.8,其他 AE 类型:13.0;比率比=1.88,95 % CI:1.12 至 2.13)期间有所上升。此外,DAE 的可预防性更高(p 结论:荷兰医院的DAE发生率在2012年得到初步改善后,在过去十年中未见进一步改善。其他AE也出现了类似的趋势。DAE的可预防率很高,这表明有很大的改进潜力,应对此进行进一步调查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Diagnosis
Diagnosis MEDICINE, GENERAL & INTERNAL-
CiteScore
7.20
自引率
5.70%
发文量
41
期刊介绍: Diagnosis focuses on how diagnosis can be advanced, how it is taught, and how and why it can fail, leading to diagnostic errors. The journal welcomes both fundamental and applied works, improvement initiatives, opinions, and debates to encourage new thinking on improving this critical aspect of healthcare quality.  Topics: -Factors that promote diagnostic quality and safety -Clinical reasoning -Diagnostic errors in medicine -The factors that contribute to diagnostic error: human factors, cognitive issues, and system-related breakdowns -Improving the value of diagnosis – eliminating waste and unnecessary testing -How culture and removing blame promote awareness of diagnostic errors -Training and education related to clinical reasoning and diagnostic skills -Advances in laboratory testing and imaging that improve diagnostic capability -Local, national and international initiatives to reduce diagnostic error
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