Experiments in vivo for Melanoma Treatment Using Laser Technology and Zirconium Dioxide-Based Dielectric Particles

Abstract

The features of thermal radiation occurrence in zirconium dioxide-based compounds doped with various rare earth (RE) ions were investigated to identify the RE ion type and excitation conditions most suitable for enhancing the thermal effect on biological tissue. Holmium-containing particles were found to emit heat upon excitation by radiation with wavelengths of 457 and 1940 nm, and thermal radiation occurs in thulium-containing particles upon excitation by radiation with a wavelength of 1940 nm. Experiments in vivo using particles studied in this work (with thulium and holmium ions) and previously (with ytterbium and erbium ions) have shown that the effect of enhancing the thermal action of laser radiation is most pronounced for ytterbium-containing particles and radiation with a wavelength of 970 nm. Experiments in vitro on mice have demonstrated the possibility of using ytterbium-containing particles when excited by laser radiation with a wavelength of 970 nm for melanoma treatment.