Sub-Chronic Peroneal Nerve Stimulation Lowers Ambulatory Blood Pressure in Spontaneously Hypertensive Rats

IF 2.7 Q3 ENGINEERING, BIOMEDICAL

IEEE Open Journal of Engineering in Medicine and Biology Pub Date : 2024-10-10 DOI:10.1109/OJEMB.2024.3477411

K. Romero;M.A. Gonzalez-Gonzalez;D. Lloyd;K. Nguyen;N. Eli;Y. Akay;W. Vongpatanasin;S. Smith;M. Akay;MI Romero-Ortega

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Abstract

Objective: Acute electrical stimulation of the common peroneal nerve (cPNS) has been shown to cause an immediate reduction in systolic blood pressure (SBP) in spontaneous hypertense rats (SHR), but the effect of this treatment in sub-chronic ambulatory SBP is unknown. Here we developed an implantable wireless WNClip neural stimulator to test the efficacy of 5-week cPNS as a treatment for hypertension. Results: Daily cPNS 2 Hz monophasic stimulation at threshold for 8 minutes every day for five weeks, reduced SBP in WKY animals by −4 mm Hg, and in SHR animals by −21 mmHg in week 5 (p < 0.01). Ambulatory SBP measured daily recorded approximately twenty-four hours after the cPNS treatment, showed a significant reduction from the first (176.6 ± 24.1 mm Hg; n = 5) to the last week of treatment (165.7± 42.7 mm Hg; n = 4), a −9 mm Hg reduction (p < 0.01). Evaluation of heart rate during the treatment showed no significant difference caused by the daily 8-minute cPNS. Conclusions: Electrical stimulation of the common peroneal nerve induced a reduction in SBP that is comparable to that reportedly achieved pharmacologically by ACE inhibitor Ramipril, or by renal denervation procedures. These results support the notion that neuromodulation of the common peroneal nerve can serve as an alternative treatment for drug resistant hypertension.

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亚慢性腓肠神经刺激可降低自发性高血压大鼠的活动血压

研究目的对腓总神经（cPNS）进行急性电刺激可立即降低自发性高血压大鼠（SHR）的收缩压（SBP），但这种治疗方法对亚慢性非卧床 SBP 的影响尚不清楚。在此，我们开发了一种植入式无线 WNClip 神经刺激器，以测试为期 5 周的 cPNS 作为高血压治疗方法的疗效。研究结果在第5周，每天对WKY动物进行阈值为2赫兹的单相刺激，持续8分钟，可使SBP下降-4毫米汞柱，SHR动物下降-21毫米汞柱（p < 0.01）。cPNS 治疗后大约 24 小时，每天测量的卧床 SBP 显示，从治疗的第一周（176.6± 24.1 mm Hg；n = 5）到最后一周（165.7± 42.7 mm Hg；n = 4），SBP 显著降低了 -9 mm Hg（p < 0.01）。对治疗期间心率的评估显示，每天 8 分钟的 cPNS 没有造成显著差异。结论对腓总神经的电刺激可降低 SBP，与 ACE 抑制剂雷米普利或肾脏去神经程序的药理作用相当。这些结果支持了这样一种观点，即腓总神经的神经调节可作为治疗耐药性高血压的替代疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Open Journal of Engineering in Medicine and Biology ENGINEERING, BIOMEDICAL-

CiteScore

9.50

自引率

3.40%

发文量

审稿时长

10 weeks

期刊介绍： The IEEE Open Journal of Engineering in Medicine and Biology (IEEE OJEMB) is dedicated to serving the community of innovators in medicine, technology, and the sciences, with the core goal of advancing the highest-quality interdisciplinary research between these disciplines. The journal firmly believes that the future of medicine depends on close collaboration between biology and technology, and that fostering interaction between these fields is an important way to advance key discoveries that can improve clinical care.IEEE OJEMB is a gold open access journal in which the authors retain the copyright to their papers and readers have free access to the full text and PDFs on the IEEE Xplore® Digital Library. However, authors are required to pay an article processing fee at the time their paper is accepted for publication, using to cover the cost of publication.