Dynamics in the Prostate Immune Microenvironment Induced by Androgen Deprivation Therapy.

IF 2.6 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Prostate Pub Date : 2024-11-24 DOI:10.1002/pros.24828

Yoshinori Yanai, Takeo Kosaka, Shuji Mikami, Masashi Arai, Keitaro Watanabe, Toshikazu Takeda, Kazuhiro Matsumoto, Makiko Yamashita, Shigehisa Kitano, Mototsugu Oya

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引用次数: 0

Abstract

Background: The influence of testosterone on the prostate's immune microenvironment remains unclear. This study aims to elucidate the dynamics of immune cells in the prostate following androgen deprivation therapy (ADT).

Methods: We retrospectively compared prostate needle biopsy and radical prostatectomy specimens from 33 patients who underwent both procedures, along with neoadjuvant ADT at a single institution. Immune cell infiltration in the cancer and stroma areas was assessed using multiplex fluorescence immunohistochemistry.

Results: Post-ADT, all immune cells, including CD4⁺ T cells, CD8⁺ T cells, Foxp3⁺ regulatory T cells, CD204⁺ macrophages, and CD20⁺ B cells, significantly increased in the prostatectomy specimen. However, few immune cells were detected in the biopsy of the same patients (p < 0.001). The number of CD20⁺ B cells in the cancer area was significantly lower post-ADT in high-risk cases according to the NCCN classification (p = 0.020). This difference was significantly associated with the Gleason Grade Group, rather than PSA levels or T classification (p < 0.001). However, no significant difference was observed in the recurrence rate between Grade Groups 1, 2, 3 and 4, 5 (p = 0.991). There was no significant difference in immune cells other than CD20⁺ B cells when divided into NCCN classifications.

Conclusions: The marked increase in immune cells following ADT suggests an intensified immune response against prostate cancer.

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雄激素剥夺疗法诱导的前列腺免疫微环境的动态变化

背景：睾酮对前列腺免疫微环境的影响仍不清楚。本研究旨在阐明雄激素剥夺疗法（ADT）后前列腺中免疫细胞的动态变化：方法：我们回顾性比较了33名患者的前列腺针刺活检和根治性前列腺切除术标本，这些患者在接受这两种治疗的同时，还在一家医疗机构接受了新辅助ADT治疗。采用多重荧光免疫组化技术评估了癌细胞和基质区的免疫细胞浸润情况：结果：ADT后，前列腺切除标本中的所有免疫细胞，包括CD4+ T细胞、CD8+ T细胞、Foxp3+调节性T细胞、CD204+巨噬细胞和CD20+ B细胞都明显增加。然而，在同一患者的活组织检查中检测到的免疫细胞却很少（根据 NCCN 分类，ADT 后高危病例癌区的 p + B 细胞明显减少（p = 0.020）。这种差异与格里森等级组明显相关，而与 PSA 水平或 T 分类（按 NCCN 分类时的 p + B 细胞）无关：ADT后免疫细胞明显增加，表明针对前列腺癌的免疫反应增强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostate 医学-泌尿学与肾脏学

CiteScore

5.10

自引率

3.60%

发文量

180

审稿时长

1.5 months

期刊介绍： The Prostate is a peer-reviewed journal dedicated to original studies of this organ and the male accessory glands. It serves as an international medium for these studies, presenting comprehensive coverage of clinical, anatomic, embryologic, physiologic, endocrinologic, and biochemical studies.