Criteria for Identifying Candidates for Systemic Psoriasis Treatment in the Real World: Application of the International Psoriasis Council Guidelines in Patients in North America.

Q3 Medicine
Bruce Strober, Yichen Zhong, Adam Sima, Alicia Beeghly, Thomas Eckmann, Eugene Balagula, Joe Zhuo, Mark Lebwohl
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引用次数: 0

Abstract

Background: The International Psoriasis Council (IPC) updated the classification of psoriasis severity to guide clinical decision-making. According to IPC guidelines, patients are considered candidates for systemic therapy when body surface area (BSA) is >10%, when lesions affect special body areas (ie, face, palms, soles, genitals, scalp, or nails), or when topical therapy fails to control symptoms.

Objective: To evaluate patient candidacy for systemic therapy in real-world settings, according to disease severity criteria.

Methods: This cross-sectional study included systemic treatment-naive patients from the CorEvitas Psoriasis Registry who initiated systemic treatment at Registry visits between April 2015 and April 2023. Based on IPC criteria, systemic therapy candidates were identified, and data on demographics and clinical characteristics, including disease severity indicators (ie, BSA and Psoriasis Area Severity Index [PASI] scores) and patient-reported outcome measures, were collected and descriptively summarized.

Results: The analysis included 2739 systemic therapy initiators with plaque psoriasis, of whom 82.7% met IPC criteria for systemic therapy. Of the 2265 systemic therapy candidates, 56.2% had a BSA >10%, 53.2% had a history of psoriasis affecting special areas, and 55.2% had prior but not current use of topical therapy. Notably, 71.0% of candidates for systemic therapy had PASI scores ≤12.

Conclusion: In this large real-world study, most patients with psoriasis who initiated systemic therapy met the IPC disease severity criteria to do so. Disease severity categorization based on PASI scores and BSA percentage alone may not adequately capture all patients who might be candidates for systemic psoriasis treatment.

Clinicaltrialsgov: NCT02707341.

在现实世界中确定系统性银屑病治疗候选者的标准:国际银屑病委员会指南在北美患者中的应用》。
背景:国际银屑病委员会(IPC)更新了银屑病严重程度分类,以指导临床决策。根据 IPC 指南,当体表面积(BSA)大于 10%、皮损影响特殊身体部位(即面部、手掌、足底、生殖器、头皮或指甲)或局部治疗无法控制症状时,患者可考虑接受系统治疗:根据疾病严重程度标准,评估患者在现实环境中是否适合接受系统治疗:这项横断面研究纳入了CorEvitas银屑病登记处的系统治疗无效患者,这些患者在2015年4月至2023年4月期间的登记访问中开始接受系统治疗。根据IPC标准,确定了系统治疗候选者,并收集和描述性总结了人口统计学和临床特征数据,包括疾病严重程度指标(即BSA和银屑病面积严重程度指数[PASI]评分)和患者报告的结果指标:分析包括2739名开始接受系统治疗的斑块状银屑病患者,其中82.7%符合系统治疗的IPC标准。在 2265 名接受系统治疗的患者中,56.2% 的患者 BSA >10%,53.2% 的患者有影响特殊部位的银屑病病史,55.2% 的患者曾接受过局部治疗,但目前没有。值得注意的是,71.0%接受系统治疗的患者的PASI评分≤12分:在这项大型真实世界研究中,大多数开始接受系统治疗的银屑病患者都符合 IPC 的疾病严重程度标准。仅根据 PASI 评分和 BSA 百分比进行疾病严重程度分类可能无法充分捕捉到所有可能接受系统性银屑病治疗的患者:NCT02707341。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
1.30
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