Soft tissue sarcomas at the single-cell and spatial resolution: new markers and targets.

IF 4.8 3区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Cancer gene therapy Pub Date : 2024-11-24 DOI:10.1038/s41417-024-00856-7

Maxim E Menyailo, Elena E Kopantseva, Anna A Khozyainova, Anastasia A Korobeynikova, Evgeny V Denisov

引用次数: 0

Abstract

Soft tissue sarcomas (STS) are heterogeneous and aggressive tumors, originating in connective tissues embryologically derived from the mesenchyme. Due to their rarity, crucial information about their biology is still lacking. In recent years, single-cell and spatial analyses have opened up new horizons in oncology, leading to the possibility of characterizing the internal architecture of the tumor at the single-cell and spatial levels. This review summarizes the first results acquired through these revolutionary methods for different types of STS. We discuss tumor cell populations and their evolution, interactions between tumor cells and the microenvironment, new prognostic markers, and clinically important targets. Finally, we examine the challenges presented by the single-cell and spatial omics of STS and the future perspectives in this field.

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单细胞和空间分辨率的软组织肉瘤：新的标记和靶标。

软组织肉瘤（STS）是一种异质性侵袭性肿瘤，起源于胚胎期来自间充质的结缔组织。由于其罕见性，有关其生物学的重要信息仍然缺乏。近年来，单细胞和空间分析为肿瘤学开辟了新天地，从而有可能在单细胞和空间水平上描述肿瘤的内部结构。本综述总结了通过这些革命性方法对不同类型的 STS 所取得的初步成果。我们将讨论肿瘤细胞群及其演变、肿瘤细胞与微环境之间的相互作用、新的预后标志物以及临床上的重要靶点。最后，我们探讨了 STS 单细胞和空间全息研究带来的挑战以及该领域的未来前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer gene therapy 医学-生物工程与应用微生物

CiteScore

10.20

自引率

0.00%

发文量

150

审稿时长

4-8 weeks

期刊介绍： Cancer Gene Therapy is the essential gene and cellular therapy resource for cancer researchers and clinicians, keeping readers up to date with the latest developments in gene and cellular therapies for cancer. The journal publishes original laboratory and clinical research papers, case reports and review articles. Publication topics include RNAi approaches, drug resistance, hematopoietic progenitor cell gene transfer, cancer stem cells, cellular therapies, homologous recombination, ribozyme technology, antisense technology, tumor immunotherapy and tumor suppressors, translational research, cancer therapy, gene delivery systems (viral and non-viral), anti-gene therapy (antisense, siRNA & ribozymes), apoptosis; mechanisms and therapies, vaccine development, immunology and immunotherapy, DNA synthesis and repair. Cancer Gene Therapy publishes the results of laboratory investigations, preclinical studies, and clinical trials in the field of gene transfer/gene therapy and cellular therapies as applied to cancer research. Types of articles published include original research articles; case reports; brief communications; review articles in the main fields of drug resistance/sensitivity, gene therapy, cellular therapy, tumor suppressor and anti-oncogene therapy, cytokine/tumor immunotherapy, etc.; industry perspectives; and letters to the editor.