Development and evaluation of quercetin topical emulgels: Physicochemical and rheological properties, stability and sun protective potential

IF 5.3 2区 化学 Q2 CHEMISTRY, PHYSICAL
Jovana Milutinov , Veljko Krstonošić , Dejan Ćirin , Miroslav Hadnađev , Maja Đanić , Nebojša Pavlović
{"title":"Development and evaluation of quercetin topical emulgels: Physicochemical and rheological properties, stability and sun protective potential","authors":"Jovana Milutinov ,&nbsp;Veljko Krstonošić ,&nbsp;Dejan Ćirin ,&nbsp;Miroslav Hadnađev ,&nbsp;Maja Đanić ,&nbsp;Nebojša Pavlović","doi":"10.1016/j.molliq.2024.126568","DOIUrl":null,"url":null,"abstract":"<div><div>Quercetin is a lipophilic natural compound that exerts various pharmacological effects such as antioxidant and anti-inflammatory, which are important in preventing skin damage by UV radiation. Emulgels are semisolid dosage forms which consist of a mixture of emulsion and gel, used for delivery of lipophilic substances. The aim of this study was to formulate a UV-protective emulgel of quercetin with proper physical and rheological properties and to examine the influence of excipients on emulgel characteristics. Eight emulgels containing 0.5 % quercetin were prepared with 0.25 % and 0.75 % carbomer 940, 10 % and 20 % castor oil and 1.5 % and 3 % Tween® 20/Span® 20 mixture (1:2). Emulgels were evaluated for their physical appearance, rheology, stability, drug release, occlusivity, and UV-protective effects. The proportion of gelling agent was the predominant factor in determining the rheological properties and the release of quercetin, while the concentration of oil phase had the greatest impact on occlusivity. Emulgels had SPF values ranging from 2.5 to 3.2 and considerable antioxidant activity. The formulation composition significantly affected the characteristics of emulgels, and to a lesser extent the UV-protective activity. Emulgel with 0.75 % gelling agent, 10 % oil phase and 1.5 % emulsifier can be considered as the optimal quercetin emulgel formulation.</div></div>","PeriodicalId":371,"journal":{"name":"Journal of Molecular Liquids","volume":"417 ","pages":"Article 126568"},"PeriodicalIF":5.3000,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Liquids","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167732224026278","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0

Abstract

Quercetin is a lipophilic natural compound that exerts various pharmacological effects such as antioxidant and anti-inflammatory, which are important in preventing skin damage by UV radiation. Emulgels are semisolid dosage forms which consist of a mixture of emulsion and gel, used for delivery of lipophilic substances. The aim of this study was to formulate a UV-protective emulgel of quercetin with proper physical and rheological properties and to examine the influence of excipients on emulgel characteristics. Eight emulgels containing 0.5 % quercetin were prepared with 0.25 % and 0.75 % carbomer 940, 10 % and 20 % castor oil and 1.5 % and 3 % Tween® 20/Span® 20 mixture (1:2). Emulgels were evaluated for their physical appearance, rheology, stability, drug release, occlusivity, and UV-protective effects. The proportion of gelling agent was the predominant factor in determining the rheological properties and the release of quercetin, while the concentration of oil phase had the greatest impact on occlusivity. Emulgels had SPF values ranging from 2.5 to 3.2 and considerable antioxidant activity. The formulation composition significantly affected the characteristics of emulgels, and to a lesser extent the UV-protective activity. Emulgel with 0.75 % gelling agent, 10 % oil phase and 1.5 % emulsifier can be considered as the optimal quercetin emulgel formulation.

Abstract Image

槲皮素外用凝胶的开发与评估:理化和流变特性、稳定性和防晒潜力
槲皮素是一种亲脂性天然化合物,具有抗氧化和消炎等多种药理作用,对防止紫外线辐射对皮肤的伤害非常重要。乳凝胶是由乳液和凝胶混合而成的半固体剂型,用于递送亲脂性物质。本研究旨在配制一种具有适当物理和流变特性的槲皮素防紫外线乳胶,并考察辅料对乳胶特性的影响。研究人员用 0.25 % 和 0.75 % 的卡波姆 940、10 % 和 20 % 的蓖麻油以及 1.5 % 和 3 % 的 Tween® 20/Span® 20 混合物(1:2)配制了八种含 0.5 % 槲皮素的乳凝胶。对乳胶的物理外观、流变性、稳定性、药物释放、吸附性和紫外线防护效果进行了评估。胶凝剂的比例是决定流变特性和槲皮素释放量的主要因素,而油相的浓度对闭合性的影响最大。乳凝胶的 SPF 值在 2.5 到 3.2 之间,具有相当高的抗氧化活性。配方成分对乳液的特性有很大影响,对紫外线防护活性的影响较小。含 0.75 % 胶凝剂、10 % 油相和 1.5 % 乳化剂的乳液可视为最佳的槲皮素乳液配方。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Molecular Liquids
Journal of Molecular Liquids 化学-物理:原子、分子和化学物理
CiteScore
10.30
自引率
16.70%
发文量
2597
审稿时长
78 days
期刊介绍: The journal includes papers in the following areas: – Simple organic liquids and mixtures – Ionic liquids – Surfactant solutions (including micelles and vesicles) and liquid interfaces – Colloidal solutions and nanoparticles – Thermotropic and lyotropic liquid crystals – Ferrofluids – Water, aqueous solutions and other hydrogen-bonded liquids – Lubricants, polymer solutions and melts – Molten metals and salts – Phase transitions and critical phenomena in liquids and confined fluids – Self assembly in complex liquids.– Biomolecules in solution The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include: – Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.) – Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.) – Light scattering (Rayleigh, Brillouin, PCS, etc.) – Dielectric relaxation – X-ray and neutron scattering and diffraction. Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信