The Veterans Affairs Rheumatoid Arthritis Registry: A unique population in rheumatoid arthritis research.

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2024-11-09 DOI:10.1016/j.semarthrit.2024.152580

Ted R Mikuls, Joshua F Baker, Grant W Cannon, Bryant R England, Gail Kerr, Andreas Reimold

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引用次数: 0

Abstract

Background: As the largest integrated healthcare system in the U.S., the Veterans Affairs (VA) provides a unique context for the conduct of clinical and clinical-translational research in rheumatoid arthritis (RA).

Objectives: To review attributes of the VA Rheumatoid Arthritis Registry (RA) and highlight its research contributions.

Findings: With >3,600 participants enrolled from 19 VA medical centers across the U.S., VARA includes longitudinally collected clinical data and a central biorepository that includes serum, plasma, and DNA collected at enrollment. VARA research capacity is enhanced via active linkages with internal data including the VA's Corporate Data Warehouse and elements captured during oncology care. This capacity is further enabled via active linkages with the National Death Index and Centers for Medicare & Medicaid Services (CMS) data.

Conclusion: As a highly unique study population with comprehensive data annotation available to researchers, VARA is poised to continue address impactful questions in RA for years to come.

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退伍军人事务类风湿关节炎登记处：类风湿关节炎研究中的独特人群。

背景：作为美国最大的综合医疗保健系统，退伍军人事务部（VA）为开展类风湿关节炎（RA）的临床和临床转化研究提供了独特的环境：目的：回顾退伍军人事务部类风湿关节炎登记处（RA）的特点，并强调其在研究方面的贡献：VARA 登记了来自全美 19 个退伍军人医疗中心的超过 3,600 名参与者，包括纵向收集的临床数据和中央生物库，其中包括登记时收集的血清、血浆和 DNA。VARA 的研究能力通过与包括退伍军人事务部企业数据仓库在内的内部数据以及肿瘤治疗过程中采集的元素的主动链接而得到增强。通过与国家死亡指数（National Death Index）和医疗保险与医疗补助服务中心（CMS）数据的积极链接，VARA 的研究能力得到了进一步提升：作为一个非常独特的研究群体，研究人员可以使用全面的数据注释，VARA 将在未来数年内继续解决 RA 中具有影响力的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.