Prognostic Value of Ceramide Dynamics in Patients with Acute Coronary Syndrome.

Studies in health technology and informatics Pub Date : 2024-11-22 DOI:10.3233/SHTI241087

Elena Usova, Alexey Yakovlev, Georgy Kopanitsa, Oleg Metsker, Madina Alieva, Tatiana Makarova, Lev Malishevskii, Ekaterina Murashko, Elizaveta Kessenikh, Sergey Trusov, Asiiat Alieva, Alexandra Konradi

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Abstract

A dynamic study of ceramide concentrations and their association with recurrent event risk could enhance our understanding of cardiovascular complications. To assess the prognostic value of ceramide concentrations (Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:1), Cer(d18:1/24:0)) and their dynamics in combination with standard clinical and laboratory parameters and therapeutic interventions in ACS patients. Among 110 ACS patients, triple blood sampling was performed for targeted lipidomic analysis using high-performance liquid chromatography-tandem mass spectrometry. All ceramide concentrations peaked at admission and decreased by the 3rd day of hospitalization and at the 3-month follow-up. The difference between Cer(d18:1/18:0) concentration 3 months after hospital discharge and its baseline value on admission was strongly associated with recurrent events, independent of prior statin treatment. The association of the Cer(d18:1/18:0) change from 3rd day of hospitalization and its baseline concentration on admission with prognosis varied depending on the glycemic profile.

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急性冠状动脉综合征患者神经酰胺动态变化的预后价值。

对神经酰胺浓度及其与复发风险的关系进行动态研究，可以加深我们对心血管并发症的了解。为了评估神经酰胺浓度（Cer(d18:1/16:0)、Cer(d18:1/18:0)、Cer(d18:1/24:1)、Cer(d18:1/24:0)）及其动态变化与标准临床和实验室参数及治疗干预相结合对 ACS 患者的预后价值。在 110 名 ACS 患者中，采用高效液相色谱-串联质谱法进行了三重血液采样，以进行有针对性的脂质体分析。所有神经酰胺浓度均在入院时达到峰值，并在住院第三天和三个月随访时下降。出院3个月后神经酰胺（d18:1/18:0）浓度与入院时基线值的差异与复发事件密切相关，与之前的他汀类药物治疗无关。住院第3天起的Cer（d18:1/18:0）浓度变化和入院时的基线浓度与预后的关系因血糖情况而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Studies in health technology and informatics

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