Correlation investigation between BDNF (Val66Met/rs6265) polymorphism and attention deficit hyperactivity disorder susceptibility in Chinese mainland population: a meta-analysis.

IF 2.3 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Psychology Health & Medicine Pub Date : 2024-11-21 DOI:10.1080/13548506.2024.2430794

Yu Lu

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Abstract

This meta-analysis evaluated the association between the Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) and the susceptibility to attention deficit hyperactivity disorder (ADHD) in the Chinese mainland population. Eligible documents were selected from online databases including PubMed, Embase, Cochrane Library, CNKI, Wanfang and CBM (updated to 15 October 2023). The evaluation of study quality was conducted according to guidelines of Newcastle-Ottawa Scale. Basic features of patients, OR and 95% CI were retrieved to assess the correlation between ADHD susceptibility and Val66Met polymorphism in four genetic models: allele genetic model (mutation (A) vs. wild-type (G)), additive genetic model (AA vs. GG and AG vs. GG), recessive genetic model (AA vs. AG+GG) and dominant genetic model (AA+AG vs. GG). This study included totally four studies for subsequent meta-analysis. The results indicated that the correlation between ADHD susceptibility and Val66Met polymorphism in A vs. G (OR = 0.8840, 95%CI: [0.6696-1.1672], p = 0.3846), AA vs. GG (OR = 0.8436, 95%CI: [0.5432-1.3102], p = 0.4490), AA+AG vs. GG (OR = 0.8602, 95%CI: [0.6497-1.1391], p = 0.2933), AG vs. GG (OR = 0.9132, 95%CI: [0.7810-1.0679], p = 0.2556) and AA vs. GG+AG (OR = 1.0315, 95%CI: [0.8789-1.2105], p = 0.7044) was not significant. Egger's test and sensitivity analysis demonstrating the reliability and stability our conclusions, respectively. BDNF Val66Met polymorphism did not contribute to the susceptibility of ADHD in Chinese mainland population.

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中国大陆人群BDNF（Val66Met/rs6265）多态性与注意缺陷多动障碍易感性的相关性研究：一项荟萃分析。

本荟萃分析评估了中国大陆人群脑源性神经营养因子（BDNF）Val66Met多态性与注意力缺陷多动障碍（ADHD）易感性之间的关系。符合条件的文献选自在线数据库，包括PubMed、Embase、Cochrane Library、CNKI、万方和CBM（更新至2023年10月15日）。研究质量评估根据纽卡斯尔-渥太华量表指南进行。检索了患者的基本特征、OR 和 95% CI，以评估多动症易感性与 Val66Met 多态性在四种遗传模式中的相关性：等位基因遗传模式（突变 (A) vs. 野生型 (G)）、加性遗传模式（AA vs. GG 和 AG vs. GG）、隐性遗传模式（AA vs. AG+GG）和显性遗传模式（AA+AG vs. GG）。本研究共纳入了四项研究进行荟萃分析。结果表明，多动症易感性与 Val66Met 多态性之间的相关性在 A vs. G（OR = 0.8840，95%CI: [0.6696-1.1672]，p = 0.3846）、AA vs. GG（OR = 0.8436，95%CI: [0.5432-1.3102]，p = 0.4490）、AA+AG vs. GG（OR = 0.8602，95%CI：[0.6497-1.1391]，p = 0.2933）、AG vs. GG（OR = 0.9132，95%CI：[0.7810-1.0679]，p = 0.2556）和 AA vs. GG+AG（OR = 1.0315，95%CI：[0.8789-1.2105]，p = 0.7044）不显著。Egger 检验和敏感性分析分别证明了我们结论的可靠性和稳定性。BDNF Val66Met多态性与中国大陆人群多动症的易感性无关。

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来源期刊

Psychology Health & Medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

6.20

自引率

0.00%

发文量

200

审稿时长

6-12 weeks

期刊介绍： Psychology, Health & Medicine is a multidisciplinary journal highlighting human factors in health. The journal provides a peer reviewed forum to report on issues of psychology and health in practice. This key publication reaches an international audience, highlighting the variation and similarities within different settings and exploring multiple health and illness issues from theoretical, practical and management perspectives. It provides a critical forum to examine the wide range of applied health and illness issues and how they incorporate psychological knowledge, understanding, theory and intervention. The journal reflects the growing recognition of psychosocial issues as they affect health planning, medical care, disease reaction, intervention, quality of life, adjustment adaptation and management. For many years theoretical research was very distant from applied understanding. The emerging movement in health psychology, changes in medical care provision and training, and consumer awareness of health issues all contribute to a growing need for applied research. This journal focuses on practical applications of theory, research and experience and provides a bridge between academic knowledge, illness experience, wellbeing and health care practice.