Causal effect between breast cancer and ovarian cancer: a two-sample mendelian randomization study.

IF 3.4 2区医学 Q2 ONCOLOGY

BMC Cancer Pub Date : 2024-11-21 DOI:10.1186/s12885-024-13033-8

Cheng Qian, Yan Xing, Wenjun Cheng

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引用次数: 0

Abstract

Objectives: Improved breast cancer (BC) outcomes highlight the importance of secondary primary cancers (SPCs) on survivor prognosis. The objective of this study was to investigate the potential genetic association between primary BC and ovarian cancer (OC), laying the groundwork for the development of preventive strategies for SPC-OC following BC surgery.

Methods: This study aimed to assess the connection between BC and OC using a two sample Mendelian randomization (MR) approach, exclusively employing aggregate level data from publicly available genome wide association studies (GWASs). Finally, the Genetic Risk Scores (GRS) method was used for secondary analysis to verify the results robustness further.

Results: The IVW method revealed a genetic correlation between Overall BC and ER + BC with Serous borderline tumors, while ER-BC exhibited genetic correlation with Mucinous borderline tumors and high-grade serous ovarian cancer. The findings from the GRS method aligned with those of the primary analysis, reinforcing the study's robustness.

Conclusion: Our MR Study identifies an association between BC and OC, highlighting the importance of increased vigilance in clinical practice for individuals with a history of BC. Timely intervention and treatment measures should be taken when necessary.

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乳腺癌与卵巢癌之间的因果效应：双样本泯灭随机研究。

目的：乳腺癌（BC）预后的改善凸显了继发性原发癌（SPC）对幸存者预后的重要性。本研究旨在调查原发性乳腺癌（BC）与卵巢癌（OC）之间潜在的遗传关联，为制定BC手术后SPC-OC的预防策略奠定基础：本研究旨在使用双样本孟德尔随机化（MR）方法评估BC与OC之间的联系，并专门采用了公开的全基因组关联研究（GWAS）的总体数据。最后，采用遗传风险评分（GRS）方法进行二次分析，以进一步验证结果的稳健性：结果：IVW方法揭示了整体BC和ER+BC与浆液性边界肿瘤之间的遗传相关性，而ER-BC则与粘液性边界肿瘤和高级别浆液性卵巢癌表现出遗传相关性。GRS方法得出的结果与主要分析的结果一致，增强了研究的稳健性：我们的 MR 研究确定了 BC 与卵巢癌之间的关联，强调了在临床实践中提高对有 BC 病史者警惕的重要性。必要时应及时采取干预和治疗措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Cancer 医学-肿瘤学

CiteScore

6.00

自引率

2.60%

发文量

1204

审稿时长

6.8 months

期刊介绍： BMC Cancer is an open access, peer-reviewed journal that considers articles on all aspects of cancer research, including the pathophysiology, prevention, diagnosis and treatment of cancers. The journal welcomes submissions concerning molecular and cellular biology, genetics, epidemiology, and clinical trials.