Cancer-Related Cognitive Impairment and the Potential of Dietary Interventions for the Prevention and Mitigation of Neurodegeneration

IF 12.5 1区医学 Q1 ONCOLOGY

Cancer research Pub Date : 2024-11-21 DOI:10.1158/0008-5472.can-24-3041

Sylvia L. Crowder, Lisa M. Gudenkauf, Aasha I. Hoogland, Hyo S. Han, Brent J. Small, Tiffany L. Carson, Nathan H. Parker, Margaret Booth-Jones, Heather S.L. Jim

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引用次数: 0

Abstract

Approximately 35% of long-term cancer survivors experience ongoing cancer-related cognitive impairment (CRCI). Yet, few efficacious interventions exist to prevent or ameliorate CRCI. The underlying biological processes driving CRCI are complex and are reported to include changes in brain structure and function, increased oxidative stress and inflammation, and alterations in gut microbiome composition. Some of the mechanisms promoting CRCI have the potential to be modified through behavioral changes, such as dietary changes. Compelling evidence from randomized controlled trials and observational research supports the positive impacts of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on cognition outside of the context of cancer, but studies investigating the MIND diet as an intervention for people who experience CRCI are lacking. This review examines the current state of the science for cognitive outcomes of dietary interventions in aging populations and discusses future opportunities to adapt these interventions to cancer populations.

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与癌症相关的认知障碍以及膳食干预在预防和缓解神经退行性病变方面的潜力

大约 35% 的长期癌症幸存者会持续出现癌症相关认知障碍 (CRCI)。然而，预防或改善 CRCI 的有效干预措施却寥寥无几。驱动 CRCI 的潜在生物过程非常复杂，据报道包括大脑结构和功能的变化、氧化应激和炎症的增加以及肠道微生物组组成的改变。促进 CRCI 的某些机制有可能通过改变行为（如改变饮食）来改变。随机对照试验和观察性研究中令人信服的证据表明，地中海-DASH 神经退行性延迟干预疗法（MIND）饮食对癌症以外的认知能力有积极影响，但将 MIND 饮食作为对 CRCI 患者的干预措施的研究还很缺乏。本综述探讨了饮食干预对老龄人群认知结果的科学现状，并讨论了将这些干预措施应用于癌症人群的未来机遇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer research 医学-肿瘤学

CiteScore

16.10

自引率

0.90%

发文量

7677

审稿时长

2.5 months

期刊介绍： Cancer Research, published by the American Association for Cancer Research (AACR), is a journal that focuses on impactful original studies, reviews, and opinion pieces relevant to the broad cancer research community. Manuscripts that present conceptual or technological advances leading to insights into cancer biology are particularly sought after. The journal also places emphasis on convergence science, which involves bridging multiple distinct areas of cancer research. With primary subsections including Cancer Biology, Cancer Immunology, Cancer Metabolism and Molecular Mechanisms, Translational Cancer Biology, Cancer Landscapes, and Convergence Science, Cancer Research has a comprehensive scope. It is published twice a month and has one volume per year, with a print ISSN of 0008-5472 and an online ISSN of 1538-7445. Cancer Research is abstracted and/or indexed in various databases and platforms, including BIOSIS Previews (R) Database, MEDLINE, Current Contents/Life Sciences, Current Contents/Clinical Medicine, Science Citation Index, Scopus, and Web of Science.