Midkine at the Crossroads of Aging and Cancer

IF 12.5 1区医学 Q1 ONCOLOGY

Cancer research Pub Date : 2024-11-21 DOI:10.1158/0008-5472.can-24-4381

Huiru Bai, Shang Cai

引用次数: 0

Abstract

Aging in mammals, including humans, is marked by a multitude of molecular, cellular, and systemic changes that increase the risk of various diseases, including cancer. While the link between aging and increased cancer incidence is well documented, the precise biological mechanisms driving tumor initiation remain less clear. In a recent issue of Cancer Cell, Yan and colleagues have identified Midkine, a heparin-binding growth factor, as an age-related biomarker mediating both ageing related phenotypes and cancer development. Further exploration of these molecular dynamics, alongside the development of targeted drugs, holds great promise for reducing aging-related cancer incidence.

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处于衰老与癌症交叉口的 Midkine

包括人类在内的哺乳动物的衰老以多种分子、细胞和系统变化为标志，这些变化增加了罹患各种疾病（包括癌症）的风险。虽然衰老与癌症发病率增加之间的联系已得到充分证实，但驱动肿瘤发生的确切生物机制仍然不太清楚。在最近一期的《癌细胞》（Cancer Cell）杂志上，Yan 及其同事发现了一种肝素结合生长因子 Midkine，它是一种与年龄相关的生物标志物，可介导衰老相关表型和癌症发展。在开发靶向药物的同时，对这些分子动态的进一步探索为降低与衰老相关的癌症发病率带来了巨大希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer research 医学-肿瘤学

CiteScore

16.10

自引率

0.90%

发文量

7677

审稿时长

2.5 months

期刊介绍： Cancer Research, published by the American Association for Cancer Research (AACR), is a journal that focuses on impactful original studies, reviews, and opinion pieces relevant to the broad cancer research community. Manuscripts that present conceptual or technological advances leading to insights into cancer biology are particularly sought after. The journal also places emphasis on convergence science, which involves bridging multiple distinct areas of cancer research. With primary subsections including Cancer Biology, Cancer Immunology, Cancer Metabolism and Molecular Mechanisms, Translational Cancer Biology, Cancer Landscapes, and Convergence Science, Cancer Research has a comprehensive scope. It is published twice a month and has one volume per year, with a print ISSN of 0008-5472 and an online ISSN of 1538-7445. Cancer Research is abstracted and/or indexed in various databases and platforms, including BIOSIS Previews (R) Database, MEDLINE, Current Contents/Life Sciences, Current Contents/Clinical Medicine, Science Citation Index, Scopus, and Web of Science.