The biochemistry of the carcinogenic alcohol metabolite acetaldehyde

IF 3 3区生物学 Q2 GENETICS & HEREDITY

DNA Repair Pub Date : 2024-11-05 DOI:10.1016/j.dnarep.2024.103782

Liam A. Thomas, Richard J. Hopkinson

引用次数: 0

Abstract

Acetaldehyde (AcH) is the first metabolite of ethanol and is proposed to be responsible for the genotoxic effects of alcohol consumption. As an electrophilic aldehyde, AcH can form multiple adducts with DNA and other biomolecules, leading to function-altering and potentially toxic and carcinogenic effects. In this review, we describe sources of AcH in humans, including AcH biosynthesis mechanisms, and outline the structures, properties and functions of AcH-derived adducts with biomolecules. We also describe human AcH detoxification mechanisms and discuss ongoing challenges in the field.

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致癌酒精代谢物乙醛的生物化学。

乙醛（Acetaldehyde，ACH）是乙醇的第一种代谢产物，被认为是造成饮酒遗传毒性效应的原因。作为一种亲电醛，AcH 可与 DNA 和其他生物大分子形成多种加合物，导致功能改变，并可能产生毒性和致癌作用。在这篇综述中，我们描述了人类体内 AcH 的来源，包括 AcH 的生物合成机制，并概述了 AcH 与生物大分子生成的加合物的结构、性质和功能。我们还描述了人类的 AcH 解毒机制，并讨论了该领域目前面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

DNA Repair 生物-毒理学

CiteScore

7.60

自引率

5.30%

发文量

审稿时长

59 days

期刊介绍： DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease. DNA Repair publishes full-length research articles, brief reports on research, and reviews. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports also will be considered for publication.