Enhanced renoprotective effects of combined glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors in type 2 diabetes mellitus: Real-world evidence.

IF 3.2 3区 医学
Jian-Yu Jhu, Yu-Wei Fang, Chung-Yen Huang, Hung-Hsiang Liou, Mon-Ting Chen, Ming-Hsien Tsai
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引用次数: 0

Abstract

Introduction: Developing a more effective treatment for the global impact of diabetic kidney disease is crucial. This study examined the renoprotective effects of combining glucagon-like peptide-1 receptor agonists (GLP-1 RA) with sodium-glucose cotransporter 2 inhibitors (SGLT2i) compared to SGLT2is alone in type 2 diabetes (DM).

Materials and methods: This retrospective cohort study used data from the TriNetX Global Collaborative Network. Type 2 DM patients with estimated glomerular filtration rates ≥60 mL/min/1.73 m2 who used GLP-1 RA or SGLT2i between January 1, 2013, and December 31, 2023. Propensity score matching balanced baseline characteristics, resulting in 71,186 patients in each group (combined GLP-1 RA and SGLT2i therapy vs SGLT2i alone). Cox regression model was adopted to compare outcomes over a 5-year period, including major adverse kidney events (MAKE), acute kidney injury (AKI), end-stage kidney disease (ESKD), and all-cause mortality.

Results: After matching, the average age was 57.1 ± 10.8 years for the GLP-1 RA plus SGLT2i group and 57.2 ± 11.7 years for the SGLT2i-only group. The GLP-1 RA plus SGLT2i group had significantly lower risk of MAKE (hazard ratio [HR]: 0.73, 95% confidence interval [CI]: 0.69-0.77), AKI (HR: 0.82, 95% C0I: 0.77-0.87), ESKD (HR: 0.61, 95% CI: 0.47-0.78), and all-cause mortality (HR: 0.54, 95% CI: 0.50-0.58) compared to the SGLT2i-only group. Moreover, subgroup analyses showed consistent benefits across different subgroups.

Conclusions: Dual therapy with GLP-1 RA and SGLT2i is supported to enhance renal outcomes and address the growing burden of diabetic kidney disease.

联合使用胰高血糖素样肽-1 受体激动剂和钠-葡萄糖共转运体 2 抑制剂可增强 2 型糖尿病患者的肾保护作用:真实世界的证据。
导言:针对糖尿病肾病的全球性影响,开发更有效的治疗方法至关重要。本研究考察了胰高血糖素样肽-1 受体激动剂(GLP-1 RA)与钠-葡萄糖共转运体 2 抑制剂(SGLT2i)联合治疗 2 型糖尿病(DM)与单独使用 SGLT2is 相比的肾保护作用:这项回顾性队列研究使用了 TriNetX 全球协作网络的数据。2013年1月1日至2023年12月31日期间使用GLP-1 RA或SGLT2i的估计肾小球滤过率≥60 mL/min/1.73 m2的2型DM患者。倾向评分匹配平衡了基线特征,每组(GLP-1 RA 和 SGLT2i 联合疗法 vs 单用 SGLT2i)共有 71186 名患者。采用 Cox 回归模型比较 5 年期间的结果,包括主要不良肾脏事件 (MAKE)、急性肾损伤 (AKI)、终末期肾病 (ESKD) 和全因死亡率:配对后,GLP-1 RA加SGLT2i组的平均年龄为(57.1 ± 10.8)岁,仅使用SGLT2i组的平均年龄为(57.2 ± 11.7)岁。与单纯 SGLT2i- 组相比,GLP-1 RA 加 SGLT2i- 组发生 MAKE(危险比 [HR]:0.73,95% 置信区间 [CI]:0.69-0.77)、AKI(HR:0.82,95% C0I:0.77-0.87)、ESKD(HR:0.61,95% CI:0.47-0.78)和全因死亡(HR:0.54,95% CI:0.50-0.58)的风险显著降低。此外,亚组分析显示,不同亚组的获益情况一致:结论:GLP-1 RA 和 SGLT2i 的双重疗法有助于改善肾脏预后,解决糖尿病肾病日益加重的负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Diabetes Investigation
Journal of Diabetes Investigation Medicine-Internal Medicine
自引率
9.40%
发文量
218
期刊介绍: Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).
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