AMPK: Balancing mitochondrial quality and quantity through opposite regulation of mitophagy pathways

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-11-21 DOI:10.1016/j.molcel.2024.10.040

Hui Jiang

引用次数: 0

Abstract

In this issue of Molecular Cell, Longo et al.¹ reveal that AMPK, a regulatory kinase activated by metabolic stress, inhibits NIX/BNIP3-dependent mitophagy to preserve mitochondrial quantity and activates PINK1/Parkin-dependent mitophagy to ensure mitochondrial quality.

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AMPK：通过对有丝分裂途径的相反调控来平衡线粒体的质量和数量

在本期《分子细胞》（Molecular Cell）杂志上，Longo 等人1揭示了由代谢压力激活的调节激酶 AMPK 可抑制 NIX/BNIP3 依赖性有丝分裂以保持线粒体数量，并激活 PINK1/Parkin 依赖性有丝分裂以确保线粒体质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.