MMOSurv: Meta-learning for few-shot survival analysis with multi-omics data.

Abstract

Motivation: High-throughput techniques have produced a large amount of high-dimensional multi-omics data, which makes it promising to predict patient survival outcomes more accurately. Recent work has showed the superiority of multi-omics data in survival analysis. However, it remains challenging to integrate multi-omics data to solve few-shot survival prediction problem, with only a few available training samples, especially for rare cancers.

Results: In this work, we propose a meta-learning framework for multi-omics few-shot survival analysis, namely MMOSurv, which enables to learn an effective multi-omics survival prediction model from a very few training samples of a specific cancer type, with the meta-knowledge across tasks from relevant cancer types. By assuming a deep Cox survival model with multiple omics, MMOSurv first learns an adaptable parameter initialization for the multi-omics survival model from abundant data of relevant cancers, and then adapts the parameters quickly and efficiently for the target cancer task with a very few training samples. Our experiments on eleven cancer types in TCGA datasets show that, compared to single-omics meta-learning methods, MMOSurv can better utilize the meta-information of similarities and relationships between different omics data from relevant cancer datasets to improve survival prediction of the target cancer with a very few multi-omics training samples. Furthermore, MMOSurv achieves better prediction performance than other state-of-the-art strategies such as multi-task learning and pre-training.

Availability and implementation: MMOSurv is freely available at https://github.com/LiminLi-xjtu/MMOSurv.

Supplementary information: Supplementary data are available at Bioinformatics online.