H K Chopra, G S Wander, Tiny Nair, C K Ponde, Navin C Nanda, Jagat Narula, Saumitra Ray, K Venugopal, S S Iyengar, R R Kasliwal, Praveen Chandra, Sunil Prakash, Sandeep Bansal, D S Rana, Prafulla Kerkar, Arup Dasbiswas, J P S Sawhney, S Shanmungasundram, Viveka Kumar, I B Vijayalakshmi, A K Pancholia, Vinod Sharma, Aditya Kapoor, H S Isser, Vishal Rastogi, Y K Arora, Ashok K Omar, Sunil Sathe, Rajeeve Rajput, D Prabhakar, G Justin Paul, Priya Jagia, Poonam Malhotra, G Suryaprakash, Vinod Mittal, Manish Jagia, A Jabir, S S Mishra, S N Routray, Ajay Kumar Sinha, Mohan Bhargava, Kiran Mahmood, Mona Bhatia, Pramila Kalra, V K Katyal, Rohit Tandon, Rahul Grover, Abhinav Chhabra, N R Shastry
{"title":"Sympathetic Overdrive and Role of Beta-blockers in Various Forms of Heart Failure: A Consensus Statement from India.","authors":"H K Chopra, G S Wander, Tiny Nair, C K Ponde, Navin C Nanda, Jagat Narula, Saumitra Ray, K Venugopal, S S Iyengar, R R Kasliwal, Praveen Chandra, Sunil Prakash, Sandeep Bansal, D S Rana, Prafulla Kerkar, Arup Dasbiswas, J P S Sawhney, S Shanmungasundram, Viveka Kumar, I B Vijayalakshmi, A K Pancholia, Vinod Sharma, Aditya Kapoor, H S Isser, Vishal Rastogi, Y K Arora, Ashok K Omar, Sunil Sathe, Rajeeve Rajput, D Prabhakar, G Justin Paul, Priya Jagia, Poonam Malhotra, G Suryaprakash, Vinod Mittal, Manish Jagia, A Jabir, S S Mishra, S N Routray, Ajay Kumar Sinha, Mohan Bhargava, Kiran Mahmood, Mona Bhatia, Pramila Kalra, V K Katyal, Rohit Tandon, Rahul Grover, Abhinav Chhabra, N R Shastry","doi":"10.59556/japi.72.0740","DOIUrl":null,"url":null,"abstract":"<p><p>In heart failure, sympathetic overdrive is evidenced by norepinephrine spillover, receptor level changes, etc. Beta-blockers continue to be the cornerstone of treatment in patients with chronic heart failure due to their ability to counteract sympathetic overdrive. Extensive clinical research has demonstrated that long-term beta-blocker treatment with metoprolol succinate, carvedilol, or bisoprolol enhances left ventricular function and reverses left ventricular remodeling, decreases hospitalization risk, and increases survival. The aim of this consensus paper is to identify patient profiles, initiation or up-titration of beta-blockers and benefits of chirally pure beta-blocker in patients with heart failure. This expert consensus will ensure precise implementation of beta-blockers in heart failure as a part of guideline-directed medical therapy.</p>","PeriodicalId":22693,"journal":{"name":"The Journal of the Association of Physicians of India","volume":"72 11","pages":"e32-e39"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of the Association of Physicians of India","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.59556/japi.72.0740","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
In heart failure, sympathetic overdrive is evidenced by norepinephrine spillover, receptor level changes, etc. Beta-blockers continue to be the cornerstone of treatment in patients with chronic heart failure due to their ability to counteract sympathetic overdrive. Extensive clinical research has demonstrated that long-term beta-blocker treatment with metoprolol succinate, carvedilol, or bisoprolol enhances left ventricular function and reverses left ventricular remodeling, decreases hospitalization risk, and increases survival. The aim of this consensus paper is to identify patient profiles, initiation or up-titration of beta-blockers and benefits of chirally pure beta-blocker in patients with heart failure. This expert consensus will ensure precise implementation of beta-blockers in heart failure as a part of guideline-directed medical therapy.
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