Recent progress in small-molecule fluorescent probes for the detection of superoxide anion, nitric oxide, and peroxynitrite anion in biological systems

IF 7.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chemical Science Pub Date : 2024-11-20 DOI:10.1039/d4sc06722c

Yongqing Zhou, Xuan Kuang, Xiaofeng Yang, Juan Li, Xianzhe Wei, Won Jun Jang, Shan-Shan Zhang, Mei Yan, Juyoung Yoon

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Abstract

Superoxide anion (O₂˙⁻), nitric oxide (NO), and peroxynitrite anion (ONOO⁻) play essential roles in physiological and pathological processes, which are related to various symptoms and diseases. There is a growing need to develop reliable techniques for effectively monitoring the changes in these three reactive species across different molecular events. Currently, small-molecule fluorescent probes have been demonstrated to be reliable imaging tools for the optical detection and biological analysis of reactive species in biological systems due to their high spatiotemporal resolution and in situ capabilities. In consideration of the distinct features of these three reactive species, abundant fluorescent probes have been developed to meet various requirements. In this context, we systematically summarized the latest progress (2020–2023) in organic fluorescent probes for monitoring O₂˙⁻, NO, and ONOO⁻ in living systems. Furthermore, the working principles and biological applications of representative fluorescent probes were illustrated. Moreover, we highlighted the current challenges and future trends of fluorescent probes, offering general insights into future research.

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用于检测生物系统中超氧化物阴离子、一氧化氮和过亚硝酸阴离子的小分子荧光探针的最新进展

超氧阴离子（O2˙-）、一氧化氮（NO）和过氧化亚硝酸阴离子（ONOO-）在生理和病理过程中发挥着重要作用，与各种症状和疾病相关。人们越来越需要开发可靠的技术，以有效监测这三种活性物种在不同分子事件中的变化。目前，小分子荧光探针因其高时空分辨率和原位功能，已被证明是生物系统中活性物种光学检测和生物分析的可靠成像工具。考虑到这三种反应物的不同特点，人们开发了丰富的荧光探针来满足各种要求。在此背景下，我们系统地总结了用于监测生命系统中 O2˙-、NO 和 ONOO- 的有机荧光探针的最新进展（2020-2023 年）。此外，还阐述了代表性荧光探针的工作原理和生物学应用。此外，我们还强调了荧光探针目前面临的挑战和未来的发展趋势，为未来的研究提供了总体启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Science CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

4.80%

发文量

1352

审稿时长

2.1 months

期刊介绍： Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.