Allylation of Lactol in Water

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-11-20 DOI:10.1021/acs.orglett.4c04189

Mengxue Zheng, Wenxiu Gao, Lei Zhang, Kaiyu Yan, Zhenguo Zhang, Peizhong Xie, Teck-Peng Loh

引用次数: 0

Abstract

We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3H)-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.

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乳醇在水中的烯丙基化

我们开发了一种在生物兼容条件下水促进 3-羟基异苯并呋喃-1(3H)-酮与烯丙基硼酸酯的交叉偶联。这种方法有助于以无金属的方式合成多种 3-烯丙基酞，并具有高产率和优异的选择性。该方法的多功能性和实用性凸显了其在药物开发和药物化学应用方面的巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.