Autoantibodies Against Dihydrolipoamide S-Acetyltransferase Are Not Associated With Immune-Mediated Neuropathies.

IF 7.8 1区医学 Q1 CLINICAL NEUROLOGY

Neurology® Neuroimmunology & Neuroinflammation Pub Date : 2025-01-01 Epub Date: 2024-11-18 DOI:10.1212/NXI.0000000000200336

Alexandre Jentzer, Jérémie El-Bechir, Guillaume Taieb, Jérôme J Devaux

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引用次数: 0

Abstract

Objectives: Dihydrolipoamide S-acetyltransferase (DLAT), the E2 component of the mitochondrial pyruvate dehydrogenase complex (PDC-E2), has recently been suggested to be a biomarker of chronic inflammatory demyelinating polyneuropathy (CIDP). It was particularly associated with sensory variants of CIDP. Antimitochondrial antibodies are important for the diagnosis of primary biliary cholangitis, but insofar, only 2 studies have reported an association with CIDP. Here, we aimed to validate these observations in a cohort of French patients with immune-mediated neuropathy.

Methods: The positivity against PDC-E2/DLAT was examined using ELISA and confirmed using commercially available immuno-DOT and by indirect immunofluorescence on stomach, kidney, and liver sections.

Results: None of the 20 healthy controls, 31 patients with Guillain-Barré syndrome, 102 patients with CIDP (including 24 patients with sensory CIDP), 26 patients with monoclonal gammopathy, 23 patients with Charcot-Marie-Tooth disease, or 20 patients with autoimmune nodopathy showed IgG against PDC-E2/DLAT.

Discussion: PDC-E2/DLAT is accurately a target antigen in immune-mediated neuropathies.

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二氢脂酰胺S-乙酰转移酶自身抗体与免疫相关性神经病无关

研究目的二氢脂酰胺 S-乙酰转移酶（DLAT）是线粒体丙酮酸脱氢酶复合物（PDC-E2）的 E2 组份，最近被认为是慢性炎症性脱髓鞘性多发性神经病（CIDP）的生物标志物。它与 CIDP 的感觉变异型尤其相关。抗线粒体抗体对于诊断原发性胆汁性胆管炎非常重要，但迄今为止，只有两项研究报告了它与 CIDP 的关联。在这里，我们的目的是在一组法国免疫介导的神经病患者中验证这些观察结果：方法：使用酶联免疫吸附试验检测 PDC-E2/DLAT 的阳性率，并使用市售免疫 DOT 和间接免疫荧光法对胃、肾和肝切片进行确认：结果：20 名健康对照组、31 名格林-巴利综合征患者、102 名 CIDP 患者（包括 24 名感觉型 CIDP 患者）、26 名单克隆丙种球蛋白病患者、23 名 Charcot-Marie-Tooth 病患者和 20 名自身免疫性结节病患者均未出现针对 PDC-E2/DLAT 的 IgG：讨论：PDC-E2/DLAT是免疫介导的神经病变的目标抗原。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology® Neuroimmunology & Neuroinflammation Neuroscience-Neurology

CiteScore

15.60

自引率

2.30%

发文量

219

审稿时长

8 weeks

期刊介绍： Neurology Neuroimmunology & Neuroinflammation is an official journal of the American Academy of Neurology. Neurology: Neuroimmunology & Neuroinflammation will be the premier peer-reviewed journal in neuroimmunology and neuroinflammation. This journal publishes rigorously peer-reviewed open-access reports of original research and in-depth reviews of topics in neuroimmunology & neuroinflammation, affecting the full range of neurologic diseases including (but not limited to) Alzheimer's disease, Parkinson's disease, ALS, tauopathy, and stroke; multiple sclerosis and NMO; inflammatory peripheral nerve and muscle disease, Guillain-Barré and myasthenia gravis; nervous system infection; paraneoplastic syndromes, noninfectious encephalitides and other antibody-mediated disorders; and psychiatric and neurodevelopmental disorders. Clinical trials, instructive case reports, and small case series will also be featured.