The Effect of Total Thyroidectomy on Trace Elements, Namely Zinc and Copper in Patients with Thyroid Diseases.

IF 0.6 Q4 SURGERY
Vahid Zand, Mohammadhossein Baradaranfar, Said Movahedinaini, Mohammad Mandegari, Mojtaba Meybodian, Sedighe Vaziribozorg, Jahanbaz Ahmadizadeh
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Abstract

The aim of this study was to investigate the effect of total thyroidectomy on serum levels of trace elements, namely zinc and copper, in patients with thyroid diseases. In this cross-sectional study, 42 patients with thyroid diseases according to laboratory and fine needle aspiration (FNA) results divided into two groups, including differentiated thyroid cancer group (papillary and follicular) and non-cancerous group (MNG: Multinodular goiter). Before the surgery, blood sample was taken to investigate the zinc and copper levels. The patients underwent total thyroidectomy. Four days after the surgery, serum zinc and copper levels were investigated again and compared. There was no significant difference in frequency of zinc (p value = 0.99) and copper (p value = 0.70) level in patients undergoing total thyroidectomy before and after the surgery. Without considering the diagnosis (MNG and PTC), zinc levels decreased significantly after the surgery (p value = 0.01) but copper levels did not differ significantly (p value = 0.93) before and after the surgery. In patients diagnosed with PTC, a significant decrease in zinc level was observed (p value = 0.04) after the surgery but the difference between the copper before and after the intervention was not significant (p value = 0.35). In patients diagnosed with MNG, no significant decrease in zinc level (p value = 0.14) and copper level (p value = 0.80) was observed after the surgery. According to the results of this study zinc serum levels had a significant decrease in patients who underwent total thyroidectomy 4 days after the surgery.

甲状腺全切除术对甲状腺疾病患者体内微量元素锌和铜的影响
本研究旨在探讨甲状腺全切除术对甲状腺疾病患者血清中微量元素锌和铜水平的影响。在这项横断面研究中,42 名甲状腺疾病患者根据实验室和细针穿刺(FNA)结果分为两组,包括分化型甲状腺癌组(乳头状和滤泡状)和非癌组(MNG:多结节性甲状腺肿)。手术前抽取血液样本检测锌和铜的含量。患者接受全甲状腺切除术。手术四天后,再次检测血清锌和铜水平并进行比较。在接受全甲状腺切除术的患者中,锌(p 值 = 0.99)和铜(p 值 = 0.70)水平在手术前后没有明显差异。在不考虑诊断(MNG 和 PTC)的情况下,手术后锌水平明显下降(p 值 = 0.01),但铜水平在手术前后没有明显差异(p 值 = 0.93)。在确诊为 PTC 的患者中,手术后锌水平明显下降(p 值 = 0.04),但干预前后铜水平差异不明显(p 值 = 0.35)。在确诊为 MNG 的患者中,手术后锌水平(p 值 = 0.14)和铜水平(p 值 = 0.80)均无明显下降。根据这项研究的结果,接受甲状腺全切除术的患者在术后4天血清锌水平明显下降。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
226
审稿时长
6-12 weeks
期刊介绍: Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress. IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc. The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world. The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members. Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.
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