Transgenic animal models for diagnosis of Disease: A hypothesis

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Vala Kafil , Benjamin Sreenan , Farzaneh Naghdi Eshratabad , Xiaoshan Zhu
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引用次数: 0

Abstract

This paper introduces a novel diagnostic approach for disease discrimination through the development of transgenic animals with highly sensitive olfactory receptor cells. Traditional diagnostic methods, such as enzyme-linked immunosorbent assay (ELISA) and nucleic acid-based amplification assay, face challenges related to false positives/negatives, limited sensitivity, or complex and costly procedures. Building on the advances in olfaction understanding and the documented ability of individuals and animals to detect diseases through scent, we propose a paradigm shift in disease diagnosis. The paper highlights the remarkable case of Joy Milne, who identified a distinct odor associated with Parkinson’s disease, leading to subsequent scientific validation. Building upon such research, we hypothesize that transgenic animals, engineered for heightened olfactory capabilities, could revolutionize disease diagnosis. The molecular recognition process and specificity of olfactory receptor cells are explored to elucidate the potential of transgenic animals in reducing the detection limit in diagnostics. Creating genetically modified animals with overexpressed olfactory receptors holds promise for early disease detection, improving prognosis and treatment outcomes. This innovative approach may significantly impact the core principles of illness diagnosis, opening up new perspectives for research and application in the field of disease diagnosis and treatment strategies.
用于疾病诊断的转基因动物模型:一种假设
本文介绍了一种新型疾病诊断方法,即通过培育具有高灵敏度嗅觉受体细胞的转基因动物进行疾病鉴别。传统的诊断方法,如酶联免疫吸附试验(ELISA)和基于核酸的扩增试验,面临着假阳性/阴性、灵敏度有限或程序复杂、成本高昂等挑战。基于对嗅觉理解的进步以及个人和动物通过气味检测疾病的能力记录,我们提出了疾病诊断模式的转变。本文重点介绍了乔伊-米尔恩(Joy Milne)的杰出案例,她发现了一种与帕金森病相关的独特气味,并在随后进行了科学验证。在此类研究的基础上,我们假设,通过改造提高嗅觉能力的转基因动物可以彻底改变疾病诊断。我们对嗅觉受体细胞的分子识别过程和特异性进行了探索,以阐明转基因动物在降低诊断中的检测极限方面的潜力。创造过度表达嗅觉受体的转基因动物有望用于早期疾病检测,改善预后和治疗效果。这种创新方法可能会对疾病诊断的核心原则产生重大影响,为疾病诊断和治疗策略领域的研究和应用开辟新的前景。
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来源期刊
Medical hypotheses
Medical hypotheses 医学-医学:研究与实验
CiteScore
10.60
自引率
2.10%
发文量
167
审稿时长
60 days
期刊介绍: Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.
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