Tumor and blood B-cell abundance outperforms established immune checkpoint blockade response prediction signatures in head and neck cancer.

IF 56.7 1区 医学 Q1 ONCOLOGY
T-G Chang, A Spathis, A A Schäffer, N Gavrielatou, F Kuo, D Jia, S Mukherjee, C Sievers, P Economopoulou, M Anastasiou, M Moutafi, L R Pal, J Vos, A S Lee, S Lam, K Zhao, P Jiang, C T Allen, P Foukas, G Gomatou, G Altan-Bonnet, L G T Morris, A Psyrri, E Ruppin
{"title":"Tumor and blood B-cell abundance outperforms established immune checkpoint blockade response prediction signatures in head and neck cancer.","authors":"T-G Chang, A Spathis, A A Schäffer, N Gavrielatou, F Kuo, D Jia, S Mukherjee, C Sievers, P Economopoulou, M Anastasiou, M Moutafi, L R Pal, J Vos, A S Lee, S Lam, K Zhao, P Jiang, C T Allen, P Foukas, G Gomatou, G Altan-Bonnet, L G T Morris, A Psyrri, E Ruppin","doi":"10.1016/j.annonc.2024.11.008","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Immunotherapy has improved the outcomes for some patients with head and neck squamous-cell carcinoma (HNSCC). However, the low and variable response rates observed highlight the need for robust response biomarkers to select patients for treatment.</p><p><strong>Patients and methods: </strong>We assembled and analyzed a large HNSCC dataset, encompassing 11 clinical cohorts including 1232 patient samples, spanning a variety of disease subtypes and immune checkpoint blockade (ICB) treatment types, tissue sources, data modalities, and timing of measurements. We conducted a comprehensive evaluation of the predictive power of various cell types, traditional biomarkers, and emerging predictors in both blood and tumor tissues of HNSCC patients.</p><p><strong>Results: </strong>Tumor B-cell infiltration emerged as a strong and robust predictor of both patient survival and ICB response. It outperformed all other established biomarkers of response to ICB, including the tertiary lymphoid structure signature and numerous T-cell-based signatures. B-cell infiltration was associated with a 'hot' antitumor microenvironment that promotes tumor eradication. Furthermore, B-cell levels in peripheral blood mononuclear cells (PBMCs) correlated strongly with tumor B-cell levels and demonstrated high predictive value for ICB response, with high odds ratios (≥7.8) in two independent clinical cohorts.</p><p><strong>Conclusion: </strong>B-cell abundance, whether assessed in PBMCs or tumor tissues, is one of the strongest predictors of ICB response in HNSCC. For translation to patient care, measuring B-cell abundance in PBMCs via cytometry offers a practical and accessible tool for clinical decision making.</p>","PeriodicalId":8000,"journal":{"name":"Annals of Oncology","volume":" ","pages":""},"PeriodicalIF":56.7000,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.annonc.2024.11.008","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Immunotherapy has improved the outcomes for some patients with head and neck squamous-cell carcinoma (HNSCC). However, the low and variable response rates observed highlight the need for robust response biomarkers to select patients for treatment.

Patients and methods: We assembled and analyzed a large HNSCC dataset, encompassing 11 clinical cohorts including 1232 patient samples, spanning a variety of disease subtypes and immune checkpoint blockade (ICB) treatment types, tissue sources, data modalities, and timing of measurements. We conducted a comprehensive evaluation of the predictive power of various cell types, traditional biomarkers, and emerging predictors in both blood and tumor tissues of HNSCC patients.

Results: Tumor B-cell infiltration emerged as a strong and robust predictor of both patient survival and ICB response. It outperformed all other established biomarkers of response to ICB, including the tertiary lymphoid structure signature and numerous T-cell-based signatures. B-cell infiltration was associated with a 'hot' antitumor microenvironment that promotes tumor eradication. Furthermore, B-cell levels in peripheral blood mononuclear cells (PBMCs) correlated strongly with tumor B-cell levels and demonstrated high predictive value for ICB response, with high odds ratios (≥7.8) in two independent clinical cohorts.

Conclusion: B-cell abundance, whether assessed in PBMCs or tumor tissues, is one of the strongest predictors of ICB response in HNSCC. For translation to patient care, measuring B-cell abundance in PBMCs via cytometry offers a practical and accessible tool for clinical decision making.

肿瘤和血液 B 细胞丰度优于头颈癌免疫检查点阻断反应预测指标
背景:免疫疗法改善了一些头颈部鳞状细胞癌(HNSCC)患者的治疗效果。然而,观察到的低反应率和可变反应率突显出需要强有力的反应生物标志物来选择接受治疗的患者:我们收集并分析了一个大型 HNSCC 数据集,其中包括 11 个临床队列、1232 份患者样本,涵盖各种疾病亚型和免疫检查点阻断疗法(ICB)治疗类型、组织来源、数据模式和测量时机。我们对 HNSCC 患者血液和肿瘤组织中各种细胞类型、传统生物标记物和新兴预测因子的预测能力进行了全面评估:结果:肿瘤 B 细胞浸润是预测患者生存期和 ICB 反应的强有力的指标。它的表现优于所有其他已确定的ICB反应生物标志物,包括三级淋巴结构特征和许多基于T细胞的特征。B细胞浸润与促进肿瘤根除的热抗肿瘤微环境有关。此外,血液单核细胞(PBMCs)中的 B 细胞水平与肿瘤 B 细胞水平密切相关,并对 ICB 反应具有很高的预测价值,在两个独立的临床队列中具有很高的几率(≥ 7.8):结论:无论是在PBMCs还是在肿瘤组织中评估B细胞丰度,B细胞丰度都是预测HNSCC对ICB反应的最有力指标之一。通过细胞测量法测量 PBMC 中 B 细胞的丰度为临床决策提供了一种实用、易用的工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Annals of Oncology
Annals of Oncology 医学-肿瘤学
CiteScore
63.90
自引率
1.00%
发文量
3712
审稿时长
2-3 weeks
期刊介绍: Annals of Oncology, the official journal of the European Society for Medical Oncology and the Japanese Society of Medical Oncology, offers rapid and efficient peer-reviewed publications on innovative cancer treatments and translational research in oncology and precision medicine. The journal primarily focuses on areas such as systemic anticancer therapy, with a specific emphasis on molecular targeted agents and new immune therapies. We also welcome randomized trials, including negative results, as well as top-level guidelines. Additionally, we encourage submissions in emerging fields that are crucial to personalized medicine, such as molecular pathology, bioinformatics, modern statistics, and biotechnologies. Manuscripts related to radiotherapy, surgery, and pediatrics will be considered if they demonstrate a clear interaction with any of the aforementioned fields or if they present groundbreaking findings. Our international editorial board comprises renowned experts who are leaders in their respective fields. Through Annals of Oncology, we strive to provide the most effective communication on the dynamic and ever-evolving global oncology landscape.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信