Gender-specific genetic influence of rs1111875 on diabetes risk: Insights from the Taiwan biobank study.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-11-18 DOI:10.1111/jdi.14359

Chih-Wei Chiang, Ying-Hsiang Chou, Chien-Ning Huang, Wen-Yu Lu, Yung-Po Liaw

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Abstract

Background: This study investigates the gender-specific genetic influence of the single nucleotide polymorphism (SNP) rs1111875 on diabetes risk within the Taiwanese population using data from the Taiwan Biobank. Diabetes mellitus, particularly type 2 diabetes (T2D), is influenced by genetic factors, and the rs1111875 SNP near the hematopoietically expressed homeobox (HHEX) gene has been linked to T2D susceptibility.

Methods: The study included 69,272 participants after excluding those from arsenic-polluted areas and those with incomplete data. Logistic regression models were used for analyses.

Results: The analyses revealed that the CT genotype of rs1111875 was associated with an increased risk of diabetes (OR = 1.092, 95% CI = 1.030-1.157, P = 0.003), as was the TT genotype (OR = 1.280, 95% CI = 1.165-1.407, P < 0.001). The effect was more pronounced in women (CT: OR = 1.118, 95% CI = 1.036-1.207, P = 0.004; TT: OR = 1.404, 95% CI = 1.243-1.585, P < 0.001). Men exhibited a higher overall risk of diabetes (OR = 1.565, 95% CI = 1.445-1.694, P < 0.001) and had a higher prevalence (12.71% vs 7.80%, P < 0.001) compared to women.

Conclusions: The findings underscore the importance of considering gender differences in genetic studies of diabetes and suggest that personalized diabetes management strategies should account for both genetic and gender-specific risk factors. This research contributes to the broader understanding of genetic determinants of diabetes and their interaction with gender, aiming to enhance personalized healthcare strategies for diabetes prevention and treatment.

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rs1111875对糖尿病风险的性别遗传影响：台湾生物库研究的启示。

研究背景本研究利用台湾生物库的数据，调查了单核苷酸多态性（SNP）rs1111875对台湾人群糖尿病风险的性别特异性遗传影响。糖尿病，尤其是 2 型糖尿病（T2D）受遗传因素的影响，而造血表达同源染色体（HHEX）基因附近的 rs1111875 SNP 与 T2D 易感性有关：研究纳入了 69 272 名参与者，但排除了来自砷污染地区和数据不完整的参与者。采用逻辑回归模型进行分析：分析结果表明，rs1111875 的 CT 基因型与糖尿病风险增加有关（OR = 1.092，95% CI = 1.030-1.157，P = 0.003），TT 基因型也与糖尿病风险增加有关（OR = 1.280，95% CI = 1.165-1.407，P 结论：rs1111875 的 CT 基因型与糖尿病风险增加有关（OR = 1.092，95% CI = 1.030-1.157，P = 0.003）：研究结果强调了在糖尿病遗传研究中考虑性别差异的重要性，并建议个性化糖尿病管理策略应考虑遗传和性别特异性风险因素。这项研究有助于人们更广泛地了解糖尿病的遗传决定因素及其与性别的相互作用，从而加强糖尿病预防和治疗的个性化医疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).