Exploring the role of Fusobacterium nucleatum in colorectal cancer: implications for tumor proliferation and chemoresistance.

IF 8.2 2区生物学 Q1 CELL BIOLOGY

Cell Communication and Signaling Pub Date : 2024-11-15 DOI:10.1186/s12964-024-01909-y

Leila Dadgar-Zankbar, Zahra Elahi, Aref Shariati, Azad Khaledi, Shabnam Razavi, Amin Khoshbayan

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引用次数: 0

Abstract

Fusobacterium nucleatum (Fn) has been extensively studied for its connection to colorectal cancer (CRC) and its potential role in chemotherapy resistance. Studies indicate that Fn is commonly found in CRC tissues and is associated with unfavorable prognosis and treatment failure. It has been shown that Fn promotes chemoresistance by affecting autophagy, a cellular process that helps cells survive under stressful conditions. Additionally, Fn targets specific signaling pathways that activate particular microRNAs and modulate the response to chemotherapy. Understanding the current molecular mechanisms and investigating the importance of Fn-inducing chemoresistance could provide valuable insights for developing novel therapies. This review surveys the role of Fn in tumor proliferation, metastasis, and chemoresistance in CRC, focusing on its effects on the tumor microenvironment, gene expression, and resistance to conventional chemotherapy drugs. It also discusses the therapeutic implications of targeting Fn in CRC treatment and highlights the need for further research.

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探索核酸分枝杆菌在结直肠癌中的作用：对肿瘤增殖和化疗耐药性的影响。

人们对核分枝杆菌（Fn）与结直肠癌（CRC）的关系及其在化疗耐药性中的潜在作用进行了广泛研究。研究表明，Fn 常见于结直肠癌组织中，并与预后不良和治疗失败有关。研究表明，Fn 通过影响自噬（一种帮助细胞在压力条件下存活的细胞过程）促进化疗耐药性。此外，Fn 还以特定的信号通路为靶点，激活特定的 microRNA 并调节对化疗的反应。了解Fn诱导化疗耐药性的现有分子机制并研究其重要性可为开发新型疗法提供有价值的见解。本综述探讨了 Fn 在 CRC 肿瘤增殖、转移和化疗耐药性中的作用，重点关注其对肿瘤微环境、基因表达和常规化疗药物耐药性的影响。它还讨论了在 CRC 治疗中靶向 Fn 的治疗意义，并强调了进一步研究的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Communication and Signaling CELL BIOLOGY-

CiteScore

11.00

自引率

0.00%

发文量

180

期刊介绍： Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior. Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.