Multi-type stroke lesion segmentation: comparison of single-stage and hierarchical approach.

Abstract

Stroke, a major cause of death and disability worldwide, can be haemorrhagic or ischaemic depending on the type of bleeding in the brain. Rapid and accurate identification of stroke type and lesion segmentation is critical for timely and effective treatment. However, existing research primarily focuses on segmenting a single stroke type, potentially limiting their clinical applicability. This study addresses this gap by exploring multi-type stroke lesion segmentation using deep learning methods. Specifically, we investigate two distinct approaches: a single-stage approach that directly segments all tissue types in one model and a hierarchical approach that first classifies stroke types and then utilises specialised segmentation models for each subtype. Recognising the importance of accurate stroke classification for the hierarchical approach, we evaluate ResNet, ResNeXt and ViT networks, incorporating focal loss and oversampling techniques to mitigate the impact of class imbalance. We further explore the performance of U-Net, U-Net++ and DeepLabV3 models for segmentation within each approach. We use a comprehensive dataset of 6650 images provided by the Ministry of Health of the Republic of Türkiye. This dataset includes 1130 ischaemic strokes, 1093 haemorrhagic strokes and 4427 non-stroke cases. In our comparative experiments, we achieve an AUC score of 0.996 when classifying stroke and non-stroke slices. For lesion segmentation task, while the performance of different architectures is comparable, the hierarchical training approach outperforms the single-stage approach in terms of intersection over union (IoU). The performance of the U-Net model increased significantly from an IoU of 0.788 to 0.875 when the hierarchical approach is used. This comparative analysis aims to identify the most effective approach and deep learning model for multi-type stroke lesion segmentation in brain CT scans, potentially leading to improved clinical decision-making, treatment efficiency and outcomes.