Blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic pain.

IF 3.2 3区 医学
Hung-Chou Kuo, Chia-Ni Lin, Sung-Sheng Tsai, Chiung-Mei Chen, Rong-Kuo Lyu, Chun-Che Chu, Long-Sun Ro, Ming-Feng Liao, Hong-Shiu Chang, Yi-Ching Weng, Jawl-Shan Hwang
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Abstract

Aims: This study aimed to identify metabolic markers for diabetic peripheral neuropathic pain (DPNP) in patients with type 2 diabetes mellitus (T2DM).

Materials and methods: Blood metabolite levels in the amino acid, biogenic amine, sphingomyelin, phosphatidylcholine (PC), carnitines, and hexose classes were analyzed in nondiabetic control (n = 27), T2DM without DPNP (n = 58), and T2DM with DPNP (n = 29) using liquid chromatography tandem mass spectrometry. Variable importance projection (VIP) evaluation by partial least squares discriminant analysis was performed on clinical parameters and metabolites.

Results: Sixteen variables with VIP > 1.0 (P < 0.05) were identified across all patient groups, and 5 variables were identified to discriminate between the two T2DM groups. DPNP patients showed elevated fasting blood glucose, glutamate, PC aa C36:1, lysoPC a C18:1, and lysoPC a C18:2, while low-density lipoprotein cholesterol, phenylalanine, and tryptophan were reduced. Glutamate, lysoPC a C18:1, and lysoPC a C18:2 discriminated T2DM with DPNP from those without DPNP with an AUC of 0.671. The AUC was improved to 0.765 when ratios of metabolite pairs were considered.

Interpretation: Blood metabolites include glutamate, and phospholipid-related metabolites implicated in neuropathic pain may have the potential as biomarkers for DPNP. Further investigation is required to understand the mechanism of action of these altered metabolites in DPNP.

伴有糖尿病周围神经痛的 2 型糖尿病患者的血液代谢组学特征。
目的:本研究旨在确定 2 型糖尿病(T2DM)患者糖尿病周围神经病理性疼痛(DPNP)的代谢标记物:采用液相色谱串联质谱法分析了非糖尿病对照组(n = 27)、无 DPNP 的 T2DM(n = 58)和有 DPNP 的 T2DM(n = 29)的血液中氨基酸、生物胺、鞘磷脂、磷脂酰胆碱(PC)、肉毒碱和己糖类代谢物水平。通过偏最小二乘判别分析对临床参数和代谢物进行了变量重要性预测(VIP)评估:结果:有 16 个变量的 VIP 值大于 1.0(P 解释性):血液代谢物包括谷氨酸和磷脂相关代谢物,这些代谢物与神经病理性疼痛有关,有可能成为 DPNP 的生物标记物。要了解这些代谢物变化在 DPNP 中的作用机制,还需要进一步的研究。
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来源期刊
Journal of Diabetes Investigation
Journal of Diabetes Investigation Medicine-Internal Medicine
自引率
9.40%
发文量
218
期刊介绍: Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).
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