One-Step Palladium-Catalyzed Heterocyclic Ring Closure of Benzofurans with Aryl Iodides through a Heck-Type Pathway

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2024-11-06 DOI:10.1021/acs.orglett.4c0360210.1021/acs.orglett.4c03602

Fathy Hassan, Nivedha Velmurugan, Yusuke Yamane, Síle Nic Chormaic and Christine K. Luscombe*,

引用次数: 0

Abstract

An operationally simple and robust method for the direct arylation and ring closure of benzofurans is reported. Besides the mild conditions and good reaction yields, the methodology is applicable for a wide range of derivatives using commercially available aryl iodides with complete C₂ regioselectivity. The reaction is proposed to follow a Heck-type oxyarylation mechanism. The facile synthesis method will enable the development of new materials for diverse applications in biology and catalysis and as precursors for organic semiconductors.

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通过 Heck 型途径一步钯催化苯并呋喃与芳基碘化物的杂环闭环反应

本报告介绍了一种操作简单、稳健的苯并呋喃直接芳基化和闭环反应方法。除了条件温和、反应收率高之外，该方法还适用于使用市售芳基碘化物的多种衍生物，并具有完全的 C2 区域选择性。该反应遵循 Heck 型氧芳基化机理。这种简便的合成方法将有助于开发在生物和催化领域有多种应用的新材料，以及用作有机半导体的前体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.