Diagnostic value of circulating IL-6 in adult sepsis: a meta-analysis.

IF 2.9 3区医学 Q1 ANESTHESIOLOGY

Minerva anestesiologica Pub Date : 2024-11-01 DOI:10.23736/S0375-9393.24.18100-X

Kao Gan, Yun Chen, Lanting Tao, Jiqiang Li

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引用次数: 0

Abstract

Introduction: In recent years, numerous studies have been published on the diagnostic performance of circulating IL-6 levels in adult sepsis, but the conclusions are not consistent. This meta-analysis aims to systematically evaluate the accuracy of circulating IL-6 in the diagnosis of adult sepsis.

Evidence acquisition: Literature on the diagnostic value of circulating IL-6 in adult sepsis published on CNKI, Wanfang Data, PubMed, Embase, Cochrane Library, and Web of Science were searched up to December 2023. QUADAS-2 scale was used to evaluate the quality of the included literature. Stata 15.0 statistical software was used for data processing. The pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) were calculated. The summary receiver operating characteristic curve (SROC) was drawn, with the area under the curve (AUC) calculated.

Evidence synthesis: A total of 31 articles were included in this meta-analysis. The results of the meta-analysis showed that the combined sensitivity, specificity, DOR, PLR, and NLR of circulating IL-6 for the diagnosis of adult sepsis were 0.74 (95%CI: 0.69-0.78), 0.73 (95%CI: 0.68-0.78), 7.71 (95%CI: 5.66-10.52), 2.77 (95%CI: 2.29-3.35), 0.36 (95%CI: 0.30-0.43), respectively. The AUC was 0.80 (95%CI: 0.76-0.83).

Conclusions: Circulating IL-6 has a good diagnostic value in adult sepsis, with moderate sensitivity and specificity. Therefore, IL-6 can provide a basis for the diagnosis of adult sepsis.

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循环 IL-6 在成人败血症中的诊断价值：一项荟萃分析。

导言：近年来，关于循环IL-6水平在成人败血症中的诊断性能的研究层出不穷，但结论并不一致。本荟萃分析旨在系统评估循环 IL-6 在成人败血症诊断中的准确性：检索了截至 2023 年 12 月在 CNKI、万方数据、PubMed、Embase、Cochrane Library 和 Web of Science 上发表的有关循环 IL-6 在成人败血症中诊断价值的文献。采用QUADAS-2量表评估纳入文献的质量。数据处理采用Stata 15.0统计软件。计算了汇总的敏感性、特异性、诊断几率比（DOR）、阳性似然比（PLR）和阴性似然比（NLR）。绘制了接收者操作特征曲线（SROC），并计算了曲线下面积（AUC）：本次荟萃分析共纳入了 31 篇文章。荟萃分析结果显示，循环 IL-6 对成人败血症诊断的综合敏感性、特异性、DOR、PLR 和 NLR 分别为 0.74（95%CI：0.69-0.78）、0.73（95%CI：0.68-0.78）、7.71（95%CI：5.66-10.52）、2.77（95%CI：2.29-3.35）、0.36（95%CI：0.30-0.43）。AUC为0.80（95%CI：0.76-0.83）：循环 IL-6 对成人败血症具有良好的诊断价值，敏感性和特异性适中。因此，IL-6 可为成人败血症的诊断提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Minerva anestesiologica 医学-麻醉学

CiteScore

4.50

自引率

21.90%

发文量

367

审稿时长

4-8 weeks

期刊介绍： Minerva Anestesiologica is the journal of the Italian National Society of Anaesthesia, Analgesia, Resuscitation, and Intensive Care. Minerva Anestesiologica publishes scientific papers on Anesthesiology, Intensive care, Analgesia, Perioperative Medicine and related fields. Manuscripts are expected to comply with the instructions to authors which conform to the Uniform Requirements for Manuscripts Submitted to Biomedical Editors by the International Committee of Medical Journal Editors.