Value of high frame rate contrast-enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinoma.

IF 4.1 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Insights into Imaging Pub Date : 2024-11-15 DOI:10.1186/s13244-024-01821-6

Xiang Fei, Lianhua Zhu, Peng Han, Bo Jiang, Miao Li, Nan Li, Ziyu Jiao, Dirk-André Clevert, Yukun Luo

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引用次数: 0

Abstract

Objectives: To investigate the value of vascular morphology on high frame rate contrast-enhanced ultrasound (H-CEUS) and CEUS Li-RADS in predicting microvascular invasion (MVI), Ki-67 expression and recurrence of hepatocellular carcinoma (HCC).

Methods: This retrospective study enrolled 78 patients with single HCC diagnosed by postoperative pathology between January 1, 2021, and June 30, 2022. All patients underwent ultrasound and H-CEUS examination before operation. H-CEUS image features and CEUS Li-RADS were compared in different MVI status and Ki-67 level. Multiple logistic regression analysis was performed to select independent variables for MVI. Differences in recurrence among different H-CEUS image features, MVI status and Ki-67 level were further analyzed.

Results: Tumor shape, vascular morphology, LR-M category, necrosis and AFP level were different between the MVI-positive group and MVI-negative group (p < 0.05). Vascular morphology and LR-M category were independent risk factors related to MVI (p < 0.05). Vascular morphology was also different between the high Ki-67 expression group and low Ki-67 expression group (p < 0.05). Vascular morphology, MVI status and Ki-67 expression were different between the recurrence group and no recurrence group (p < 0.05).

Conclusion: The vascular morphology of HCC on H-CEUS can indicate the risk of MVI status, Ki-67 expression and recurrence, which provides a feasible imaging technique for predicting the prognosis before operation.

Critical relevance statement: H-CEUS shows the different vascular morphology of HCC in arterial phase and indicates the risk of MVI, Ki-67 expression and recurrence, which provides a feasible imaging technique for clinician to judge the risk of MVI pre-operation and adopt appropriate treatment.

Key points: H-CEUS can clearly show different vascular morphology of HCC in arterial phase. Vascular morphology on H-CEUS is associated with MVI status, Ki-67 expression and HCC recurrence. Preoperative MVI and Ki-67 expression prediction could help surgeons choose a more appropriate treatment plan.

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高帧率对比增强超声波在预测肝癌微血管侵犯方面的价值。

目的研究高帧率对比增强超声（H-CEUS）和 CEUS Li-RADS 上的血管形态在预测微血管侵犯（MVI）、Ki-67 表达和肝细胞癌（HCC）复发方面的价值：这项回顾性研究纳入了 2021 年 1 月 1 日至 2022 年 6 月 30 日期间经术后病理诊断为单发 HCC 的 78 例患者。所有患者均在术前接受了超声和 H-CEUS 检查。比较了不同MVI状态和Ki-67水平下的H-CEUS图像特征和CEUS Li-RADS。进行多元逻辑回归分析以选择MVI的独立变量。进一步分析了不同H-CEUS图像特征、MVI状态和Ki-67水平之间的复发差异：结果：MVI阳性组与MVI阴性组的肿瘤形态、血管形态、LR-M分类、坏死和AFP水平均不同（PH-CEUS显示的HCC血管形态可显示MVI状态、Ki-67表达和复发的风险，为术前预测预后提供了一种可行的成像技术：H-CEUS可显示HCC在动脉期的不同血管形态，并提示MVI、Ki-67表达和复发的风险，为临床医生在术前判断MVI风险并采取适当治疗提供了可行的影像学技术：要点：H-CEUS可清晰显示HCC在动脉期的不同血管形态。H-CEUS上的血管形态与MVI状态、Ki-67表达和HCC复发有关。术前MVI和Ki-67表达预测可帮助外科医生选择更合适的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

7.30

自引率

4.30%

发文量

182

审稿时长

13 weeks

期刊介绍： Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.