Ligand-controlled palladium-catalyzed regiodivergent aminocarbonylation of tert-alcohols

Abstract

Alcohols are widely available, abundant, and diverse in both commercial and natural resources. They possess low toxicity, making their use as reactants for carbonylation extremely promising. Herein, we present a robust ligand-controlled regioselective aminocarbonylation of tert-alcohols. Utilizing a commercially available palladium salt and ligand as the catalytic system, various amides containing an α-quaternary carbon or β-substituted amides can be selectively accessible. Notably, water is the only by-product of this reaction, which is consistent with the concept of green chemistry. This protocol offers a broad substrate scope, high regioselectivity, and excellent performance in scale-up reactions.