Pediatric Hodgkin Lymphoma in Low- and Middle-Income Countries (LMICs). A Narrative Review.

IF 2 4区医学 Q3 HEMATOLOGY

Mediterranean Journal of Hematology and Infectious Diseases Pub Date : 2024-11-01 eCollection Date: 2024-01-01 DOI:10.4084/MJHID.2024.078

Maria Luisa Moleti, Anna Maria Testi, Salma Al-Hadad, Mazin Faisal Al-Jadiry, Robin Foà

引用次数: 0

Abstract

Pediatric Hodgkin lymphoma (HL) is a curable disease for more than 90% of children and adolescents in high-income countries. However, similar results cannot be achieved, particularly for advanced disease, in low- and middle-income countries (LMICs), where challenging socio-economic realities and the consequent scarcity of local resources heavily impact the treatment and patients' outcome. Information regarding the management and outcome of pediatric HL in LMICs is still limited. In this narrative review, we summarize the results reported in the literature so far and discuss the critical key points that have emerged from this overview.

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中低收入国家（LMICs）小儿霍奇金淋巴瘤。叙述性综述。

在高收入国家，90% 以上的儿童和青少年都能治愈小儿霍奇金淋巴瘤（HL）。然而，在中低收入国家（LMICs），尤其是晚期疾病患者却无法获得类似的治疗效果，因为这些国家面临着严峻的社会经济现实，因此当地资源匮乏，这严重影响了治疗和患者的预后。有关中低收入国家儿科 HL 的管理和疗效的信息仍然有限。在这篇叙述性综述中，我们总结了迄今为止文献报道的结果，并讨论了综述中出现的关键要点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mediterranean Journal of Hematology and Infectious Diseases Medicine-Hematology

CiteScore

4.20

自引率

6.20%

发文量

113

审稿时长

12 weeks

期刊介绍： Reciprocal interdependence between infectious and hematologic diseases (malignant and non-malignant) is well known. This relationship is particularly evident in Mediterranean countries. Parasitosis as Malaria, Leishmaniosis, B Hookworms, Teniasis, very common in the southeast Mediterranean area, infect about a billion people and manifest prevalently with anemia so that they are usually diagnosed mostly by experienced hematologist on blood or bone marrow smear. On the other hand, infections are also a significant problem in patients affected by hematological malignancies. The blood is the primary vector of HIV infection, which otherwise manifest with symptoms related to a reduction in T lymphocytes. In turn, infections can favor the insurgency of hematological malignancies. The causative relationship between Epstein-Barr virus infection, Helicobacter pylori, hepatitis C virus, HIV and lymphoproliferative diseases is well known.