Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) dietary exposure is associated with an increased risk of type 2 diabetes in the European prospective investigation into cancer and nutrition (EPIC) cohort

IF 4.6 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & metabolism Pub Date : 2024-11-01 DOI:10.1016/j.diabet.2024.101587

Xuan Ren , Geneviève Nicolas , Pauline Frenoy , Keren Papier , Conchi Moreno-Iribas , Giovanna Masala , Christina C. Dahm , Jie Zhang , Franziska Jannasch , Matthias B. Schulze , Elisabete Weiderpass , Paolo Chiodini , Claudia Vener , Paolo Vineis , Alicia K. Heath , Fulvio Ricceri , Sandra M. Colorado-Yohar , Chloé Marques , Thibault Fiolet , Gianluca Severi , Francesca Romana Mancini

{"title":"Non-dioxin-like polychlorinated biphenyls (NDL-PCBs) dietary exposure is associated with an increased risk of type 2 diabetes in the European prospective investigation into cancer and nutrition (EPIC) cohort","authors":"Xuan Ren , Geneviève Nicolas , Pauline Frenoy , Keren Papier , Conchi Moreno-Iribas , Giovanna Masala , Christina C. Dahm , Jie Zhang , Franziska Jannasch , Matthias B. Schulze , Elisabete Weiderpass , Paolo Chiodini , Claudia Vener , Paolo Vineis , Alicia K. Heath , Fulvio Ricceri , Sandra M. Colorado-Yohar , Chloé Marques , Thibault Fiolet , Gianluca Severi , Francesca Romana Mancini","doi":"10.1016/j.diabet.2024.101587","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims/hypothesis</h3><div>The aim of the present study was to investigate the association between dietary exposures to dioxins, dioxin-like polychlorinated biphenyls (DL-PCBs) and non-dioxin-like polychlorinated biphenyls (NDL-PCBs) and the incidence of type 2 diabetes mellitus (T2DM) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.</div></div><div><h3>Methods</h3><div>This prospective cohort study with a median 11.7 years of follow-up, included 318,416 individuals recruited in 21 centers in eight countries. Dietary intake of dioxins and PCBs was calculated by combining EPIC food consumption data with food contamination data from the European Food Safety Authority (EFSA). To identify incident cases of T2DM, a thorough review of various sources including self-reported information, linkage to primary and secondary care registers, drug registers, hospital admissions, and mortality data was conducted. Associations between dietary intake of dioxins and PCBs and T2DM were evaluated using multivariable Cox regressions.</div></div><div><h3>Results</h3><div>Higher T2DM risk was observed for higher estimated dietary intake of non-dioxin-like PCBs (NDL-PCBs; HR <sub>per 1 SD increment</sub> = 1.03 [95 %CI 1.01;1.04], and HR <sub>(Q4</sub> <sub>vs Q1)</sub> = 1.15 [1.08;1.22], <em>P</em>-trend < 0.001). The results were consistent in analyses stratified by gender, body mass index, country, median follow-up, or self-reported hypertension and hyperlipidemia, as well as when adjusting for fat intake. No consistent association was observed between dioxins+DL-PCBs intake and T2DM risk.</div></div><div><h3>Conclusion / interpretation</h3><div>Results obtained in this large European prospective study indicate a positive and linear association between dietary intake of NDL-PCBs and risk of T2DM. This association remained consistent across various stratified and sensitivity analyses. Further studies are warranted to better understand the biological mechanisms underlying this association.</div></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 6","pages":"Article 101587"},"PeriodicalIF":4.6000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes & metabolism","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S126236362400079X","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Aims/hypothesis

The aim of the present study was to investigate the association between dietary exposures to dioxins, dioxin-like polychlorinated biphenyls (DL-PCBs) and non-dioxin-like polychlorinated biphenyls (NDL-PCBs) and the incidence of type 2 diabetes mellitus (T2DM) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Methods

This prospective cohort study with a median 11.7 years of follow-up, included 318,416 individuals recruited in 21 centers in eight countries. Dietary intake of dioxins and PCBs was calculated by combining EPIC food consumption data with food contamination data from the European Food Safety Authority (EFSA). To identify incident cases of T2DM, a thorough review of various sources including self-reported information, linkage to primary and secondary care registers, drug registers, hospital admissions, and mortality data was conducted. Associations between dietary intake of dioxins and PCBs and T2DM were evaluated using multivariable Cox regressions.

Results

Higher T2DM risk was observed for higher estimated dietary intake of non-dioxin-like PCBs (NDL-PCBs; HR _{per 1 SD increment} = 1.03 [95 %CI 1.01;1.04], and HR _(Q4 _{vs Q1)} = 1.15 [1.08;1.22], P-trend < 0.001). The results were consistent in analyses stratified by gender, body mass index, country, median follow-up, or self-reported hypertension and hyperlipidemia, as well as when adjusting for fat intake. No consistent association was observed between dioxins+DL-PCBs intake and T2DM risk.

Conclusion / interpretation

Results obtained in this large European prospective study indicate a positive and linear association between dietary intake of NDL-PCBs and risk of T2DM. This association remained consistent across various stratified and sensitivity analyses. Further studies are warranted to better understand the biological mechanisms underlying this association.

查看原文本刊更多论文

在欧洲癌症与营养前瞻性调查（EPIC）队列中，非二恶英类多氯联苯（NDL-PCBs）膳食暴露与 2 型糖尿病风险增加有关。

目的/假设：本研究旨在调查欧洲癌症与营养前瞻性调查（EPIC）队列中二恶英、二恶英类多氯联苯（DL-PCBs）和非二恶英类多氯联苯（NDL-PCBs）的膳食暴露与 2 型糖尿病（T2DM）发病率之间的关系：这项前瞻性队列研究的中位随访时间为 11.7 年，包括 8 个国家 21 个中心招募的 318416 人。二恶英和多氯联苯的膳食摄入量是通过将 EPIC 的食品消费数据与欧洲食品安全局（EFSA）的食品污染数据相结合计算得出的。为了确定 T2DM 的发病病例，对各种来源的数据进行了全面审查，包括自我报告的信息、与初级和二级医疗登记、药物登记、入院和死亡数据的关联。采用多变量考克斯回归法评估了二恶英和多氯联苯的膳食摄入量与 T2DM 之间的关系：结果：非二恶英类多氯联苯（NDL-PCBs；HR 每 1 SD 增量 = 1.03 [95%CI 1.01;1.04]，HR (Q4 vs Q1) = 1.15 [1.08;1.22], P-趋势 < 0.001）的估计膳食摄入量越高，T2DM 风险越高。按性别、体重指数、国家、随访中位数或自我报告的高血压和高脂血症进行分层分析，以及对脂肪摄入量进行调整后，结果一致。在二恶英+DL-多氯联苯摄入量与T2DM风险之间没有发现一致的关联：这项大型欧洲前瞻性研究的结果表明，膳食中 NDL-PCBs 的摄入量与 T2DM 风险之间呈线性正相关。在各种分层分析和敏感性分析中，这种关联仍然保持一致。为了更好地了解这种关联的生物机制，有必要开展进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Diabetes & metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.20%

发文量

审稿时长

13 days

期刊介绍： A high quality scientific journal with an international readership Official publication of the SFD, Diabetes & Metabolism, publishes high-quality papers by leading teams, forming a close link between hospital and research units. Diabetes & Metabolism is published in English language and is indexed in all major databases with its impact factor constantly progressing. Diabetes & Metabolism contains original articles, short reports and comprehensive reviews.