Unveiling the hidden world of transfer RNA-derived small RNAs in inflammation.

IF 4.4 3区医学 Q2 IMMUNOLOGY

Journal of Inflammation-London Pub Date : 2024-11-12 DOI:10.1186/s12950-024-00418-6

Peiru Qiu, Qi Jiang, Haojun Song

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引用次数: 0

Abstract

Transfer RNA-derived small RNAs (tsRNAs) are a newly discovered class of small noncoding RNAs (sncRNAs) that include tRNA-derived stress-induced RNAs (tiRNAs) and tRNA-derived fragments (tRFs). Following the development of high-throughput sequencing technology, an increasing number of tsRNAs have been discovered with vital functions in different physiological and pathophysiological processes. Extensive research has revealed that tsRNAs are involved in various diseases, such as cancers, autoimmune illnesses and other diseases. This review focuses on the role and significance of tsRNAs in inflammation, such as the regulation of substances including inflammatory inducers, inflammatory cells and inflammatory factors, which contribute to the pathogenesis of inflammation-related diseases. Moreover, we discuss in-depth the molecular pathogenic mechanisms of tsRNAs in inflammation-related diseases through different signaling pathways and assess their clinical value, providing new perspectives for the exploration of tsRNA functions and inflammation-related diseases.

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揭开炎症中转运核糖核酸衍生小核糖核酸的隐秘世界。

转运核糖核酸衍生的小核糖核酸（tsRNAs）是一类新发现的小非编码核糖核酸（sncRNAs），包括转运核糖核酸衍生的应激诱导核糖核酸（tiRNAs）和转运核糖核酸衍生的片段（tRFs）。随着高通量测序技术的发展，越来越多在不同生理和病理生理过程中具有重要功能的 tsRNA 被发现。广泛的研究发现，tsRNAs 与癌症、自身免疫性疾病和其他疾病等多种疾病有关。本综述重点探讨 tsRNAs 在炎症中的作用和意义，如调控炎症诱导剂、炎症细胞和炎症因子等物质，这些物质是炎症相关疾病的发病机制。此外，我们还深入探讨了 tsRNA 通过不同信号通路在炎症相关疾病中的分子致病机制，并评估了其临床价值，为探索 tsRNA 的功能和炎症相关疾病提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Inflammation-London IMMUNOLOGY-

CiteScore

7.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Inflammation welcomes research submissions on all aspects of inflammation. The five classical symptoms of inflammation, namely redness (rubor), swelling (tumour), heat (calor), pain (dolor) and loss of function (functio laesa), are only part of the story. The term inflammation is taken to include the full range of underlying cellular and molecular mechanisms involved, not only in the production of the inflammatory responses but, more importantly in clinical terms, in the healing process as well. Thus the journal covers molecular, cellular, animal and clinical studies, and related aspects of pharmacology, such as anti-inflammatory drug development, trials and therapeutic developments. It also considers publication of negative findings. Journal of Inflammation aims to become the leading online journal on inflammation and, as online journals replace printed ones over the next decade, the main open access inflammation journal. Open access guarantees a larger audience, and thus impact, than any restricted access equivalent, and increasingly so, as the escalating costs of printed journals puts them outside University budgets. The unrestricted access to research findings in inflammation aids in promoting dynamic and productive dialogue between industrial and academic members of the inflammation research community, which plays such an important part in the development of future generations of anti-inflammatory therapies.