Employing innovation to enhance the safety and reliability of restorative surgical techniques for patients with familial adenomatous polyposis at a national referral centre.

IF 2.7 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Techniques in Coloproctology Pub Date : 2024-11-09 DOI:10.1007/s10151-024-03021-2

B A Alves Martins, A Shamsiddinova, G H T Worley, Y-J Hsu, Victoria Cuthill, M Hawkins, A Sinha, J T Jenkins, D Miskovic, S K Clark, O D Faiz

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引用次数: 0

Abstract

Introduction: Restorative proctocolectomy (RPC) and total colectomy with ileorectal anastomosis (TC-IRA) are traditional surgical options for individuals with familial adenomatous polyposis (FAP). Re-appraisal and modification to these techniques, such as near-total colectomy with ileo-distal sigmoid anastomosis (NT-IDSA) and RPC with robotic intracorporeal single-stapled anastomosis (RPC-RiSSA), have been implemented in recent years. This study aimed to evaluate the early postoperative outcomes associated with novel techniques employed in a single centre for restorative surgery in patients with FAP.

Methods: A retrospective analysis was conducted using data from patients with FAP who underwent prophylactic restorative surgery between January 2008 and December 2022 at St Mark's Hospital.

Results: Two hundred fifty-three individuals underwent restorative surgery over the 15-year period; 102/253 (40.3%) underwent TC-IRA, 84 (33.2%) had NT-IDSA, and 67 (26.5%) underwent RPC. Laparoscopic approach was the most common (88.2%) operative access. Seventeen patients (6.7%) underwent robotic operations. For robotic-assisted procedures, no conversions were reported. No anastomotic leaks or 30-day reoperations were reported in the NT-IDSA group compared to 8% (0/84 vs 8/102, p = 0.009) and 11% (0/84 vs 11/102, p = 0.002), respectively, in the TC-IRA group. Regarding RPC, following the introduction of robotic RPC-RiSSA in 2019, no anastomotic leakage was observed compared with 9% (0/11 vs 5/56, p = 0.3) in those undergoing conventional RPC.

Conclusion: Our institution has transitioned from TC-IRA to NT-IDSA since 2014 and conventional RPC to RPC-RiSSA in 2019. To date, since refinement of the techniques there have been no anastomotic failures amongst these cohorts. The reported results may offer future horizons for patients undergoing similar procedures for alternative colorectal diseases.

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在国家转诊中心采用创新技术，提高家族性腺瘤性息肉病患者修复手术技术的安全性和可靠性。

简介：修复性直结肠切除术（RPC）和全结肠切除加回直肠吻合术（TC-IRA）是家族性腺瘤性息肉病（FAP）患者的传统手术选择。近年来，对这些技术进行了重新评估和修改，如近全结肠切除术加回肠-直肠乙状结肠吻合术（NT-IDSA）和RPC加机器人体腔内单缝合吻合术（RPC-RiSSA）。本研究旨在评估一个单一中心采用新技术对 FAP 患者进行修复手术的早期术后效果：方法：采用2008年1月至2022年12月期间在圣马克医院接受预防性修复手术的FAP患者的数据进行回顾性分析：15年间共有253人接受了修复手术，其中102/253人（40.3%）接受了TC-IRA，84人（33.2%）接受了NT-IDSA，67人（26.5%）接受了RPC。腹腔镜是最常见的手术入路（88.2%）。17名患者（6.7%）接受了机器人手术。在机器人辅助手术中，没有关于转换手术的报告。NT-IDSA组未报告吻合口漏或30天内再次手术，而TC-IRA组分别为8%（0/84 vs 8/102, p = 0.009）和11%（0/84 vs 11/102, p = 0.002）。关于RPC，在2019年引入机器人RPC-RiSSA后，没有观察到吻合口漏，而接受传统RPC的患者则有9%（0/11 vs 5/56，p = 0.3）：我院自 2014 年起从 TC-IRA 过渡到 NT-IDSA，并于 2019 年从传统 RPC 过渡到 RPC-RiSSA。迄今为止，自技术改进以来，这些队列中没有发生过吻合失败。所报告的结果为接受类似手术治疗其他结直肠疾病的患者提供了未来的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Techniques in Coloproctology GASTROENTEROLOGY & HEPATOLOGY-SURGERY

CiteScore

5.30

自引率

9.10%

发文量

176

审稿时长

1 months

期刊介绍： Techniques in Coloproctology is an international journal fully devoted to diagnostic and operative procedures carried out in the management of colorectal diseases. Imaging, clinical physiology, laparoscopy, open abdominal surgery and proctoperineology are the main topics covered by the journal. Reviews, original articles, technical notes and short communications with many detailed illustrations render this publication indispensable for coloproctologists and related specialists. Both surgeons and gastroenterologists are represented on the distinguished Editorial Board, together with pathologists, radiologists and basic scientists from all over the world. The journal is strongly recommended to those who wish to be updated on recent developments in the field, and improve the standards of their work. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1965 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted. Reports of animal experiments must state that the Principles of Laboratory Animal Care (NIH publication no. 86-23 revised 1985) were followed as were applicable national laws (e.g. the current version of the German Law on the Protection of Animals). The Editor-in-Chief reserves the right to reject manuscripts that do not comply with the above-mentioned requirements. Authors will be held responsible for false statements or for failure to fulfill such requirements.