Prognostic impact of adipose tissue loss at 1 month after surgery in patients with gastric cancer.

IF 2.3 3区医学 Q2 SURGERY

World Journal of Surgery Pub Date : 2024-11-14 DOI:10.1002/wjs.12370

Itaru Hashimoto, Keisuke Komori, Shizune Onuma, Hayato Watanabe, Hideaki Suematsu, Shinsuke Nagasawa, Kazuki Kano, Taiichi Kawabe, Toru Aoyama, Tsutomu Hayashi, Takanobu Yamada, Tsutomu Sato, Aya Saito, Takashi Ogata, Haruhiko Cho, Takaki Yoshikawa, Yasushi Rino, Takashi Oshima

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引用次数: 0

Abstract

Background: The postoperative impact of short-term changes in skeletal muscle loss (SML) and adipose tissue loss (ATL) on treatment outcomes is unclear in patients with gastric cancer (GC). We investigate the role of SML and ATL at 1 month after surgery in determining postoperative survival and recurrence rates in patients with GC.

Methods: We analyzed 540 patients with GC and assessed their skeletal muscle mass, visceral fat mass, and subcutaneous fat mass using computed tomography scans preoperatively and 1 month postoperatively. Patients were categorized into high and low groups based on their levels of SML, visceral ATL (v-ATL), and subcutaneous ATL (s-ATL). Additionally, they were classified into three groups (high ATL, intermediate ATL, and low ATL) based on their v-ATL and s-ATL measurements.

Results: Patients with higher v-ATL and s-ATL had lower overall survival (OS) and recurrence-free survival (RFS) rates. High ATL was an independent prognostic factor for decreased OS (hazard ratio [HR] 2.27; 95% confidence interval [CI] 1.16-4.42; and P = 0.02) and RFS (HR 2.51; 95% CI 1.34-4.71; and P = 0.004) rates.

Conclusion: A reduction in adipose tissue volume shortly after surgery (1 month) could potentially indicate an increased risk of recurrence and mortality in patients with GC.

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胃癌患者术后 1 个月脂肪组织丢失对预后的影响。

背景：胃癌（GC）患者术后骨骼肌损失（SML）和脂肪组织损失（ATL）的短期变化对治疗效果的影响尚不明确。我们研究了术后 1 个月骨骼肌和脂肪组织丢失对胃癌患者术后生存率和复发率的影响：我们对 540 名胃癌患者进行了分析，并在术前和术后 1 个月使用计算机断层扫描评估了他们的骨骼肌质量、内脏脂肪质量和皮下脂肪质量。根据 SML、内脏 ATL（v-ATL）和皮下 ATL（s-ATL）的水平，将患者分为高、低两组。此外，还根据 v-ATL 和 s-ATL 测量值将患者分为三组（高 ATL、中等 ATL 和低 ATL）：结果：v-ATL和s-ATL较高的患者总生存率（OS）和无复发生存率（RFS）较低。高ATL是OS（危险比[HR] 2.27；95%置信区间[CI] 1.16-4.42；P = 0.02）和RFS（HR 2.51；95%置信区间[CI] 1.34-4.71；P = 0.004）率降低的独立预后因素：结论：术后不久（1 个月）脂肪组织体积的减少可能预示着 GC 患者复发和死亡风险的增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Surgery 医学-外科

CiteScore

5.10

自引率

3.80%

发文量

460

审稿时长

3 months

期刊介绍： World Journal of Surgery is the official publication of the International Society of Surgery/Societe Internationale de Chirurgie (iss-sic.com). Under the editorship of Dr. Julie Ann Sosa, World Journal of Surgery provides an in-depth, international forum for the most authoritative information on major clinical problems in the fields of clinical and experimental surgery, surgical education, and socioeconomic aspects of surgical care. Contributions are reviewed and selected by a group of distinguished surgeons from across the world who make up the Editorial Board.