Allogeneic hematopoietic cell transplantation in elderly patients with myelodysplastic syndromes: Considerations and challenges.

IF 5 3区医学 Q1 HEMATOLOGY

Seminars in hematology Pub Date : 2024-10-17 DOI:10.1053/j.seminhematol.2024.10.004

Eduard Schulz, Steven Z Pavletic, Alain Mina

引用次数: 0

Abstract

Myelodysplastic syndromes/neoplasms (MDS) and related diseases are highly heterogeneous myeloid stem cell cancers that predominantly affect the elderly. The only curative treatment is allogeneic hematopoietic cell transplantation (HCT). Given the prevalence of age-related comorbidities, HCT in patients aged 65 years or older requires a highly personalized approach. This review summarizes disease risk stratification, treatment modalities, and outcomes for patients with MDS and related disorders, and discusses specific considerations and challenges for elderly patients undergoing HCT, including geriatric assessment, timing, conditioning treatment, donor and graft selection, and graft-versus-host disease prophylaxis.

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骨髓增生异常综合征老年患者的异基因造血细胞移植：考虑因素和挑战。

骨髓增生异常综合征/肿瘤（MDS）及相关疾病是高度异质性的骨髓干细胞癌症，主要影响老年人。唯一可治愈的治疗方法是异基因造血细胞移植（HCT）。鉴于年龄相关合并症的普遍性，65 岁或以上患者的 HCT 需要高度个性化的方法。本综述总结了 MDS 及相关疾病患者的疾病风险分层、治疗方式和疗效，并讨论了老年患者接受 HCT 的具体注意事项和挑战，包括老年评估、时机选择、调理治疗、供体和移植物选择以及移植物抗宿主病预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in hematology 医学-血液学

CiteScore

6.20

自引率

2.80%

发文量

审稿时长

35 days

期刊介绍： Seminars in Hematology aims to present subjects of current importance in clinical hematology, including related areas of oncology, hematopathology, and blood banking. The journal''s unique issue structure allows for a multi-faceted overview of a single topic via a curated selection of review articles, while also offering a variety of articles that present dynamic and front-line material immediately influencing the field. Seminars in Hematology is devoted to making the important and current work accessible, comprehensible, and valuable to the practicing physician, young investigator, clinical practitioners, and internists/paediatricians with strong interests in blood diseases. Seminars in Hematology publishes original research, reviews, short communications and mini- reviews.