Association of NTRK2 gene with suicidality: a meta-analysis.

IF 1.5 4区 医学 Q4 GENETICS & HEREDITY
Psychiatric Genetics Pub Date : 2024-12-01 Epub Date: 2024-11-06 DOI:10.1097/YPG.0000000000000373
Wenzhu Ye, Ruo Su Zhang, Georgina M Hosang, Chiara Fabbri, Nicole King, John Strauss, Ian Jones, Lisa Jones, Gerome Breen, James L Kennedy, John B Vincent, Clement C Zai
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引用次数: 0

Abstract

Background: Previous studies have shown that genes in brain development pathways may have important roles in affecting risk of suicidal behaviors, with our previous meta-analysis supporting a role of the brain-derived neurotrophic factor (BDNF) gene. NTRK2 is a gene that encodes the neurotrophic receptor tyrosine kinase 2, which is a receptor for BDNF. In the current study, we aim to examine the potential association between NTRK2 single nucleotide polymorphism (SNPs) and suicidal ideation/behaviors.

Methods: We first conducted a literature search using keywords like 'NTRK2', 'TRKB', and 'suicid*' to identify papers on NTRK2 SNPs and suicidal ideation/behaviors. In addition, we have individual-level genotype data for all the identified SNPs in literature search. We used the R meta package to perform meta-analyses on both the genotype count and the allele count data. Moreover, we performed meta-analyses on specific haplotypes within each haplotype block.

Main results: Following our literature search and meta-analyses on 20 NTRK2 SNPs across up to 8467 samples, we found three SNPs, rs10868235 [N = 5,318, odds ratio (OR) = 1.34, P = 0.02], rs1867283 (N = 5,134, OR = 0.73, P = 0.04), and rs1147198 (N = 5,132, OR = 1.36, P = 0.03) to be nominally associated with suicidal attempts. Those three findings, however, did not survive multiple-testing corrections. Also, none of the haplotype blocks showed significant involvement in suicidality.

Conclusion: Our results suggest that the NTRK2 gene may not have a major role in suicidality. Future efforts, however, should explore gene-gene interaction and pathway analyses.

NTRK2基因与自杀倾向的关系:一项荟萃分析。
背景:以往的研究表明,大脑发育途径中的基因可能在影响自杀行为风险方面起着重要作用,我们之前的荟萃分析支持脑源性神经营养因子(BDNF)基因的作用。NTRK2 是一个编码神经营养受体酪氨酸激酶 2 的基因,它是 BDNF 的受体。本研究旨在探讨 NTRK2 单核苷酸多态性(SNPs)与自杀意念/行为之间的潜在关联:我们首先使用'NTRK2'、'TRKB'和'suicid*'等关键词进行文献检索,以找出有关NTRK2 SNPs和自杀意念/行为的论文。此外,我们还拥有文献检索中所有已识别 SNPs 的个体水平基因型数据。我们使用 R meta 软件包对基因型计数和等位基因计数数据进行了荟萃分析。此外,我们还对每个单倍型区块中的特定单倍型进行了元分析:在对多达 8467 个样本中的 20 个 NTRK2 SNPs 进行文献检索和元分析后,我们发现 rs10868235 [N=5318,几率比(OR)= 1.34,P=0.02]、rs1867283(N=5134,OR=0.73,P=0.04)和 rs1147198(N=5132,OR=1.36,P=0.03)这三个 SNPs 与自杀未遂名义上相关。然而,这三个结果并没有通过多重检验校正。此外,没有一个单倍型区块显示与自杀倾向有显著关系:结论:我们的研究结果表明,NTRK2 基因在自杀倾向中的作用可能并不大。结论:我们的研究结果表明,NTRK2 基因在自杀倾向中可能并不扮演重要角色。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Psychiatric Genetics
Psychiatric Genetics 医学-神经科学
CiteScore
2.30
自引率
0.00%
发文量
39
审稿时长
3 months
期刊介绍: ​​​​​​The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.
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