Modulation of Local Field Potentials in the Deep Brain of Minipigs Through Transcranial Temporal Interference Stimulation.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY

Neuromodulation Pub Date : 2024-11-08 DOI:10.1016/j.neurom.2024.10.002

Hsiao-Chun Lin, Yi-Hui Wu, Ming-Dou Ker

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引用次数: 0

Abstract

Objectives: Transcranial temporal interference stimulation (tTIS) is a novel, noninvasive neuromodulation technique to modulate deep brain neural activity. Despite its potential, direct electrophysiological evidence of tTIS effects remains limited. This study investigates the impact of tTIS on local field potentials (LFPs) in the deep brain using minipigs implanted with deep brain electrodes.

Materials and methods: Three minipigs were implanted with electrodes in the subthalamic nucleus, and tTIS was applied using patch electrode pairs positioned on both sides of the scalp. Stimulation was delivered in sinewave voltage mode with intensities ≤2V. We evaluated the stimulus-response relationship, effects of different carrier frequencies, the range of entrained envelope oscillations, and changes resulting from adjusting the left-right stimulation intensity ratio.

Results: The results indicated that tTIS modulates deep-brain LFPs in an intensity-dependent manner. Carrier frequencies of 1 or 2 kHz were most effective in influencing LFP. Envelope oscillations <200 Hz were effectively entrained into deep-brain LFPs. Adjustments to the stimulation intensity ratio between the left and right sides yielded inconsistent responses, with right-sided stimulation playing a dominant role.

Conclusion: These findings indicate that tTIS can regulate LFP changes in the deep brain, highlighting its potential as a promising tool for future noninvasive neuromodulation applications.

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通过经颅颞叶干扰刺激调节迷你猪大脑深部的局部场电位

目的：经颅颞部干扰刺激（tTIS）是一种新型的非侵入性神经调控技术，用于调节大脑深部神经活动。尽管经颅颞区干扰刺激很有潜力，但其效果的直接电生理学证据仍然有限。本研究利用植入大脑深部电极的迷你猪，研究了 tTIS 对大脑深部局部场电位（LFPs）的影响：在三只小猪的丘脑下核植入电极，并使用位于头皮两侧的贴片电极对其施加 tTIS。刺激以正弦波电压模式进行，强度≤2V。我们评估了刺激-反应关系、不同载波频率的影响、夹带包络振荡的范围以及调整左右刺激强度比所产生的变化：结果表明，tTIS 以强度依赖的方式调节深脑 LFP。载波频率为 1 或 2 kHz 对 LFP 的影响最为有效。包络振荡结论：这些研究结果表明，tTIS 可以调节大脑深部的 LFP 变化，突出了其作为未来无创神经调控应用工具的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuromodulation 医学-临床神经学

CiteScore

6.40

自引率

3.60%

发文量

978

审稿时长

54 days

期刊介绍： Neuromodulation: Technology at the Neural Interface is the preeminent journal in the area of neuromodulation, providing our readership with the state of the art clinical, translational, and basic science research in the field. For clinicians, engineers, scientists and members of the biotechnology industry alike, Neuromodulation provides timely and rigorously peer-reviewed articles on the technology, science, and clinical application of devices that interface with the nervous system to treat disease and improve function.