[Control of growth hormone release by growth hormone-releasing factor and prostaglandin E2 in a system of perfused rat anterior pituitary cells].

Abstract

Using superfused rat pituitary cells we showed that the growth hormone-releasing factor (GRF) and prostaglandin E2 (PGE2) increased growth hormone (GH) secretion in a similar manner in terms of kinetics and amplitude of responses. Moreover, our data suggest that they stimulate GH secretion mainly by cAMP-dependent mechanisms.