Identification of a novel vardenafil analogue, 19-O-propyl hydroxy vardenafil, as a dietary supplement adulterant.

IF 3.1 3区医学 Q2 CHEMISTRY, ANALYTICAL

Journal of pharmaceutical and biomedical analysis Pub Date : 2024-11-04 DOI:10.1016/j.jpba.2024.116563

Hui-Chun Lee, You-Lun Wu, Yu-Ting Lin, Li-Yao Tsai, Ya-Min Kao, Mei-Chih Lin, Su-Hsiang Tseng

引用次数: 0

Abstract

A novel vardenafil analogue was discovered during adulterant screening of a dietary supplement. After extraction and purification, this analogue was identified using liquid chromatography-high resolution mass spectrometry (LC-HRMS) and nuclear magnetic resonance (NMR) analyses. The molecular formula determined using LC-HRMS was C₂₄H₃₄N₆O₅S. Fragmentation data suggested that this unknown compound may have two modifications to vardenafil. NMR analysis confirmed the presence of a hydroxyl group on the piperazine moiety and a propyl group attached to the phenoxy group. Consequently, this compound was named 19-O-propyl hydroxy vardenafil.

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鉴定新型伐地那非类似物19-O-丙基羟基伐地那非为膳食补充剂掺假物。

在对一种膳食补充剂进行掺假筛选时发现了一种新型伐地那非类似物。经过提取和纯化，利用液相色谱-高分辨质谱（LC-HRMS）和核磁共振（NMR）分析鉴定出了这种类似物。液相色谱-高分辨质谱（LC-HRMS）测定的分子式为 C24H34N6O5S。碎片数据表明，这种未知化合物可能对伐地那非进行了两种修饰。核磁共振分析证实，哌嗪分子上有一个羟基，苯氧基上有一个丙基。因此，这种化合物被命名为 19-O-丙基羟基伐地那非。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of pharmaceutical and biomedical analysis 医学-分析化学

CiteScore

6.70

自引率

5.90%

发文量

588

审稿时长

37 days

期刊介绍： This journal is an international medium directed towards the needs of academic, clinical, government and industrial analysis by publishing original research reports and critical reviews on pharmaceutical and biomedical analysis. It covers the interdisciplinary aspects of analysis in the pharmaceutical, biomedical and clinical sciences, including developments in analytical methodology, instrumentation, computation and interpretation. Submissions on novel applications focusing on drug purity and stability studies, pharmacokinetics, therapeutic monitoring, metabolic profiling; drug-related aspects of analytical biochemistry and forensic toxicology; quality assurance in the pharmaceutical industry are also welcome. Studies from areas of well established and poorly selective methods, such as UV-VIS spectrophotometry (including derivative and multi-wavelength measurements), basic electroanalytical (potentiometric, polarographic and voltammetric) methods, fluorimetry, flow-injection analysis, etc. are accepted for publication in exceptional cases only, if a unique and substantial advantage over presently known systems is demonstrated. The same applies to the assay of simple drug formulations by any kind of methods and the determination of drugs in biological samples based merely on spiked samples. Drug purity/stability studies should contain information on the structure elucidation of the impurities/degradants.