Implications of molecular classifications in glioma surgery.

IF 3.2 2区医学 Q2 CLINICAL NEUROLOGY

Journal of Neuro-Oncology Pub Date : 2024-11-12 DOI:10.1007/s11060-024-04883-0

Anita L Kalluri, Joyce H Lee, Calixto-Hope G Lucas, Jordina Rincon-Torroella, Chetan Bettegowda

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Abstract

Purpose: The incorporation of molecular markers into neuro-oncology has transformed our understanding of adult diffuse gliomas. While surgical resection is the mainstay of treatment for many patients with gliomas, surgical management strategies warrant re-exploration in the context of characteristic molecular profiles.

Methods: We reviewed the neurosurgical and neuro-oncological literature for studies investigating surgery in molecularly defined cohorts of adult diffuse gliomas.

Results: We discuss key molecular markers associated with the three subtypes of adult diffuse glioma: glioblastoma IDH-wildtype, astrocytoma IDH-mutant, and oligodendroglioma IDH-mutant and 1p/19q codeleted. We additionally discuss surgical strategies and extent of resection in these tumors, framing them in the context of key molecular alterations. Finally, we briefly discuss the practical utility of molecular markers in guiding surgical decision making.

Conclusion: Molecular markers in gliomas are of growing relevance to surgical intervention. Advancements in preoperative and intraoperative molecular diagnostics will increase the utility of molecular biomarkers in informing surgical decision-making for patients with gliomas.

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胶质瘤手术中分子分类的意义。

目的：将分子标记纳入神经肿瘤学改变了我们对成人弥漫性胶质瘤的认识。虽然手术切除是许多胶质瘤患者的主要治疗方法，但手术治疗策略需要在特征性分子图谱的背景下进行重新探讨：方法：我们查阅了神经外科和神经肿瘤学文献，以了解在分子定义的成人弥漫性胶质瘤组群中进行手术的研究情况：结果：我们讨论了与成人弥漫性胶质瘤三种亚型相关的关键分子标记物：胶质母细胞瘤IDH野生型、星形细胞瘤IDH突变型和少突胶质瘤IDH突变型及1p/19q编码缺失型。此外，我们还讨论了这些肿瘤的手术策略和切除范围，并以关键的分子改变为背景进行了阐述。最后，我们简要讨论了分子标记物在指导手术决策方面的实际效用：胶质瘤的分子标记物与手术干预的相关性越来越大。术前和术中分子诊断的进步将提高分子生物标志物在指导胶质瘤患者手术决策中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuro-Oncology 医学-临床神经学

CiteScore

6.60

自引率

7.70%

发文量

277

审稿时长

3.3 months

期刊介绍： The Journal of Neuro-Oncology is a multi-disciplinary journal encompassing basic, applied, and clinical investigations in all research areas as they relate to cancer and the central nervous system. It provides a single forum for communication among neurologists, neurosurgeons, radiotherapists, medical oncologists, neuropathologists, neurodiagnosticians, and laboratory-based oncologists conducting relevant research. The Journal of Neuro-Oncology does not seek to isolate the field, but rather to focus the efforts of many disciplines in one publication through a format which pulls together these diverse interests. More than any other field of oncology, cancer of the central nervous system requires multi-disciplinary approaches. To alleviate having to scan dozens of journals of cell biology, pathology, laboratory and clinical endeavours, JNO is a periodical in which current, high-quality, relevant research in all aspects of neuro-oncology may be found.