A multimodal imaging approach to investigate retinal oxygen and vascular dynamics, and neural dysfunction in bietti crystalline dystrophy

IF 2.9 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Microvascular research Pub Date : 2024-11-08 DOI:10.1016/j.mvr.2024.104762

Shiyi Yin , Jinyuan Wang , Jingyuan Zhu , Ximeng Feng , Haihan Zhang , Haowen Li , Jingying Xiu , Chuanqing Zhou , Qiushi Ren , Wenbin Wei

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引用次数: 0

Abstract

Background

This study aimed to explore retinal changes in Bietti crystalline dystrophy (BCD) patients, including retinal metabolism, blood flow, vascular remodeling, and pupillary light reflex (PLR) abnormalities.

Methods

This cross-sectional study included 120 eyes from BCD patients and 120 eyes from healthy controls, utilizing a multimodal imaging system (MEFIAS 3200, SYSEYE, Chongqing, China) to evaluate retinal oxygenation, blood flow, vascular structure, and PLR. Measurements included oxygen saturation, blood flow velocity, vessel diameters, and pulsatility metrics. PLR parameters were assessed under specific light stimuli.

Results

BCD patients demonstrated significantly higher retinal oxygen saturation and content, but lower oxygen utilization and metabolism compared to controls, with more pronounced declines in those over 40 years old. Vascular parameters revealed smaller external diameters and larger lumen diameters, indicating vascular remodeling. Retinal blood flow was lower, while the resistivity index was higher in BCD patients. Additionally, PLR abnormalities were noted, including reduced constriction amplitude, pupil constriction ratio, constriction duration, and maximum constriction velocity, along with prolonged latency were observed in BCD patients.

Conclusion

BCD patients had significant retinal and vascular changes, along with PLR impairments, especially in patients over 40. More targeted interventions should be focused in future research.

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用多模态成像方法研究 bietti 晶体营养不良症患者视网膜氧和血管动态以及神经功能障碍。

背景：本研究旨在探讨Bietti晶体营养不良症（BCD）患者视网膜的变化，包括视网膜代谢、血流、血管重塑和瞳孔对光反射（PLR）异常：这项横断面研究纳入了120名BCD患者和120名健康对照者，利用多模态成像系统（MEFIAS 3200，SYSEYE，中国重庆）评估视网膜氧合、血流、血管结构和瞳孔对光反射。测量项目包括血氧饱和度、血流速度、血管直径和脉动指标。PLR参数在特定光刺激下进行评估：结果：与对照组相比，BCD 患者的视网膜氧饱和度和含量明显较高，但氧利用率和新陈代谢较低，40 岁以上的患者下降更为明显。血管参数显示外径变小，管腔直径变大，表明血管重塑。BCD 患者的视网膜血流量较低，而电阻率指数较高。此外，BCD 患者还发现 PLR 异常，包括收缩幅度、瞳孔收缩比、收缩持续时间和最大收缩速度降低，以及潜伏期延长：结论：BCD 患者的视网膜和血管发生了明显变化，并伴有 PLR 损伤，尤其是 40 岁以上的患者。今后的研究应重点关注更有针对性的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microvascular research 医学-外周血管病

CiteScore

6.00

自引率

3.20%

发文量

158

审稿时长

43 days

期刊介绍： Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured. Research Areas include: • Angiogenesis • Biochemistry • Bioengineering • Biomathematics • Biophysics • Cancer • Circulatory homeostasis • Comparative physiology • Drug delivery • Neuropharmacology • Microvascular pathology • Rheology • Tissue Engineering.