Life-Threatening Methaemoglobinaemia Secondary to Cetrimide.

Q3 Medicine

European journal of case reports in internal medicine Pub Date : 2024-09-26 eCollection Date: 2024-01-01 DOI:10.12890/2024_004837

Radwan Zeidan, Mohammed Abdallah, Nazem Matta, Patricia Nehme, Mirna Fares

{"title":"Life-Threatening Methaemoglobinaemia Secondary to Cetrimide.","authors":"Radwan Zeidan, Mohammed Abdallah, Nazem Matta, Patricia Nehme, Mirna Fares","doi":"10.12890/2024_004837","DOIUrl":null,"url":null,"abstract":"Methaemoglobinaemia is a rare but potentially life-threatening condition in which there is diminution of the oxygen-carrying capacity of the circulating haemoglobin. It can result from either congenital or acquired processes. Acquired methaemoglobinaemia is more prevalent than congenital methaemoglobinaemia, and notably it has a higher prevalence in infants and neonates than in adults; it results from exposure to oxidising agents. Methaemoglobin forms when haemoglobin is oxidised to contain iron in the ferric (Fe3+) state rather than the normal ferrous (Fe2+) state. Methaemoglobinaemia is a clinical diagnosis and is suspected in the presence of hypoxaemia refractory to supplemental oxygen and in the presence of chocolate-coloured blood. Symptoms are usually dependent on the methaemoglobin levels; at levels higher than 35%, systemic symptoms from tissue hypoxia may be fatal. We present a case of severe life-threatening methaemoglobinaemia following intra-abdominal use of cetrimide during hydatid cyst removal in a 60-year-old female.Learning points: Cetrimide can cause methaemoglobinaemia when used as a protoscolicidal agent during the surgical treatment of hydatid cysts.Severe methaemoglobinaemia has high mortality rate and is usually missed and not easily diagnosed.","PeriodicalId":11908,"journal":{"name":"European journal of case reports in internal medicine","volume":"11 11","pages":"004837"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542940/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of case reports in internal medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12890/2024_004837","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Methaemoglobinaemia is a rare but potentially life-threatening condition in which there is diminution of the oxygen-carrying capacity of the circulating haemoglobin. It can result from either congenital or acquired processes. Acquired methaemoglobinaemia is more prevalent than congenital methaemoglobinaemia, and notably it has a higher prevalence in infants and neonates than in adults; it results from exposure to oxidising agents. Methaemoglobin forms when haemoglobin is oxidised to contain iron in the ferric (Fe³⁺) state rather than the normal ferrous (Fe²⁺) state. Methaemoglobinaemia is a clinical diagnosis and is suspected in the presence of hypoxaemia refractory to supplemental oxygen and in the presence of chocolate-coloured blood. Symptoms are usually dependent on the methaemoglobin levels; at levels higher than 35%, systemic symptoms from tissue hypoxia may be fatal. We present a case of severe life-threatening methaemoglobinaemia following intra-abdominal use of cetrimide during hydatid cyst removal in a 60-year-old female.

Learning points: Cetrimide can cause methaemoglobinaemia when used as a protoscolicidal agent during the surgical treatment of hydatid cysts.Severe methaemoglobinaemia has high mortality rate and is usually missed and not easily diagnosed.

查看原文本刊更多论文

继发于西曲嘧啶的危及生命的高铁血红蛋白血症。

高铁血红蛋白血症是一种罕见但可能危及生命的疾病，循环血红蛋白的携氧能力会降低。它可能由先天性或后天性过程引起。获得性高铁血红蛋白血症比先天性高铁血红蛋白血症更常见，尤其是在婴儿和新生儿中的发病率高于成年人；它是由于接触氧化剂所致。当血红蛋白被氧化成含有铁（Fe3+）状态的铁而不是正常的亚铁（Fe2+）状态时，就会形成高铁血红蛋白。甲铁血红蛋白血症是一种临床诊断方法，如果出现低氧血症而补充氧气又难以奏效，并且血液呈巧克力色，就有可能是甲铁血红蛋白血症。症状通常取决于高铁血红蛋白水平；当高铁血红蛋白水平高于 35% 时，组织缺氧引起的全身症状可能是致命的。我们介绍了一例 60 岁女性在腹腔内使用西曲嘧啶切除包虫囊肿后出现严重的高铁血红蛋白血症，危及生命的病例：学习要点：在手术治疗包虫囊肿的过程中，西曲肽作为原体杀菌剂使用时可能会引起高铁血红蛋白血症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European journal of case reports in internal medicine

CiteScore

2.10

自引率

0.00%

发文量

166

审稿时长

8 weeks

期刊介绍： The European Journal of Case Reports in Internal Medicine is an official journal of the European Federation of Internal Medicine (EFIM), representing 35 national societies from 33 European countries. The Journal''s mission is to promote the best medical practice and innovation in the field of acute and general medicine. It also provides a forum for internal medicine doctors where they can share new approaches with the aim of improving diagnostic and clinical skills in this field. EJCRIM welcomes high-quality case reports describing unusual or complex cases that an internist may encounter in everyday practice. The cases should either demonstrate the appropriateness of a diagnostic/therapeutic approach, describe a new procedure or maneuver, or show unusual manifestations of a disease or unexpected reactions. The Journal only accepts and publishes those case reports whose learning points provide new insight and/or contribute to advancing medical knowledge both in terms of diagnostics and therapeutic approaches. Case reports of medical errors, therefore, are also welcome as long as they provide innovative measures on how to prevent them in the current practice (Instructive Errors). The Journal may also consider brief and reasoned reports on issues relevant to the practice of Internal Medicine, as well as Abstracts submitted to the scientific meetings of acknowledged medical societies.