Optimization and application of renal depth measurement method in the cadmium-zinc-telluride‑based SPECT/CT renal dynamic imaging.

IF 3 2区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

EJNMMI Physics Pub Date : 2024-11-15 DOI:10.1186/s40658-024-00702-7

Hongyuan Zheng, Xiangxiang Li, Shen Wang, Shasha Hou, Chunling Shi, Xue Li, Qiang Jia, Wei Zheng

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引用次数: 0

Abstract

Purpose: This study aims to evaluate the accuracy of four kidney depth measurement methods-nuclear medicine tomography, nuclear medicine lateral scanning, ultrasound, and Tonnesen's formula-based estimation-using CT measurements as the reference standard. Additionally, it investigates the feasibility of utilizing nuclear medicine tomography and lateral scanning for measuring kidney depth in ^99mTc-DTPA renal dynamic imaging.

Methods: Hollow kidney phantoms mimicking the shape and volume of adult kidneys were 3D printed and filled with ^99mTcO₄^- solution. These phantoms were then subjected to lateral scanning and nuclear medicine tomography using CZT (cadmium-zinc-telluride) SPECT/CT to determine the optimal post-processing method. Forty patients who underwent renal dynamic imaging were recruited for the study. Renal depths were derived from ultrasound, lateral imaging, nuclear medicine tomography, formula-based estimation, and CT measurements. The renal depths obtained through these four methods were for correlation with CT-measured renal depths. Additionally, the absolute differences between renal depths obtained by each method and the CT standard were analyzed and compared across groups.

Results: Using kidney phantoms, nuclear medicine tomography images were processed with a Butterworth filter (cutoff frequency = 0.6), and renal outlines in lateral images was manually delineated. In the clinical validation phase, correlation coefficients indicated strong associations between renal depths measured by nuclear medicine tomography (left kidney: R = 0.885, P < 0.05; right kidney: R = 0.927, P < 0.05) and lateral scanning (left kidney: R = 0.933, P < 0.05; right kidney: R = 0.956, P < 0.05) compared to CT measurements. The difference in kidney depth between nuclear medicine tomography and CT measurements were the smallest and statistically significant (left kidney: 0.69 ± 0.51; right kidney: 0.58 ± 0.41, P < 0.05).

Conclusion: Using ordered subset expectation maximization (OSEM) in conjunction with a Butterworth filter (fc = 0.6) as the post-processing method, nuclear medicine tomography enables more accurate renal depth measurements without increasing the radiation dose to patients.

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基于镉锌碲化物的SPECT/CT肾脏动态成像中肾脏深度测量方法的优化与应用

目的：本研究旨在以 CT 测量为参考标准，评估四种肾脏深度测量方法--核医学断层扫描、核医学侧位扫描、超声波和基于 Tonnesen 公式的估算--的准确性。此外，它还研究了在 99mTc-DTPA 肾脏动态成像中利用核医学断层扫描和侧向扫描测量肾脏深度的可行性。方法：模拟成人肾脏形状和体积的空心肾脏模型是三维打印的，并填充了 99mTcO4- 溶液。然后对这些模型进行横向扫描，并使用 CZT（碲锌镉）SPECT/CT 进行核医学断层成像，以确定最佳的后处理方法。研究招募了 40 名接受肾脏动态成像的患者。肾脏深度由超声波、侧位成像、核医学断层扫描、公式估算和 CT 测量得出。通过这四种方法获得的肾脏深度与 CT 测量的肾脏深度进行相关性分析。此外，还分析了每种方法获得的肾深度与 CT 标准肾深度之间的绝对差异，并在各组间进行了比较：使用肾脏模型，用巴特沃斯滤波器（截止频率=0.6）处理核医学断层图像，并人工勾画侧位图像中的肾脏轮廓。在临床验证阶段，相关系数表明核医学断层扫描测量的肾脏深度之间有很强的关联性（左肾：R = 0.885，P 结论：R = 0.885，P 结论：R = 0.885，P 结论：R = 0.885：使用有序子集期望最大化（OSEM）结合巴特沃斯滤波器（fc = 0.6）作为后处理方法，核医学断层扫描能在不增加患者辐射剂量的情况下更准确地测量肾脏深度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

EJNMMI Physics Physics and Astronomy-Radiation

CiteScore

6.70

自引率

10.00%

发文量

审稿时长

13 weeks

期刊介绍： EJNMMI Physics is an international platform for scientists, users and adopters of nuclear medicine with a particular interest in physics matters. As a companion journal to the European Journal of Nuclear Medicine and Molecular Imaging, this journal has a multi-disciplinary approach and welcomes original materials and studies with a focus on applied physics and mathematics as well as imaging systems engineering and prototyping in nuclear medicine. This includes physics-driven approaches or algorithms supported by physics that foster early clinical adoption of nuclear medicine imaging and therapy.