Large-scale omics analyses of nutrition-responsive mechanisms of female germline stem cell proliferation and maintenance in Drosophila melanogaster

IF 5.8 1区农林科学 Q1 BIOLOGY

Current opinion in insect science Pub Date : 2024-11-08 DOI:10.1016/j.cois.2024.101296

Ryosuke Hayashi , Ryusuke Niwa

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引用次数: 0

Abstract

Female germline stem cells (fGSCs) are essential for generating mature oocytes. In general, self-renewal and differentiation of fGSCs into germ cells are regulated by niche signals from neighboring niche cells. In addition, fGSCs and their niche cells are greatly influenced by physiological and environmental factors, especially nutritional status. To clarify molecular mechanisms involved in regulating fGSC proliferation and maintenance, the fruit fly Drosophila melanogaster has served as an excellent genetic model organism. In recent years, along with sophisticated genetic tools for D. melanogaster, large-scale transcriptome, proteome, and metabolome analyses have provided new insights into D. melanogaster fGSC biology. These large-scale analyses have identified new markers and regulators for D. melanogaster fGSCs, including Netrin-A, Helical factor, eggplant, Gr43a, and genes controlling the polyol pathway, some of which are involved in nutrient-responsive control of fGSC behavior.

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黑腹果蝇雌性生殖干细胞增殖和维持的营养响应机制的大规模全局分析。

雌性生殖干细胞（fGSCs）对生成成熟卵母细胞至关重要。一般来说，生殖干细胞的自我更新和向生殖细胞的分化受邻近生态位细胞的生态位信号调控。此外，fGSCs 及其壁龛细胞受生理和环境因素（尤其是营养状况）的影响很大。为阐明调控fGSC增殖和维持的分子机制，果蝇一直是很好的遗传模式生物。近年来，随着黑腹果蝇遗传工具的成熟，大规模转录组、蛋白质组和代谢组分析为黑腹果蝇基因组干细胞生物学提供了新的见解。这些大规模分析发现了黑腹蝇果胶质细胞的新标记和调控因子，包括Netrin-A、螺旋因子、茄子、Gr43a和控制多元醇途径的基因，其中一些基因参与了果胶质细胞行为的营养响应控制。

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来源期刊

Current opinion in insect science BIOLOGYECOLOGYENTOMOLOGY-ECOLOGY

CiteScore

10.40

自引率

1.90%

发文量

113

期刊介绍： Current Opinion in Insect Science is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up–to–date with the expanding volume of information published in the field of Insect Science. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following 11 areas are covered by Current Opinion in Insect Science. -Ecology -Insect genomics -Global Change Biology -Molecular Physiology (Including Immunity) -Pests and Resistance -Parasites, Parasitoids and Biological Control -Behavioural Ecology -Development and Regulation -Social Insects -Neuroscience -Vectors and Medical and Veterinary Entomology There is also a section that changes every year to reflect hot topics in the field. Section Editors, who are major authorities in their area, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors commission articles from leading scientists on each topic that they have selected and the commissioned authors write short review articles in which they present recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.