Association between RDW-SD and prognosis across glycemic status in patients with dilated cardiomyopathy.

IF 3.7 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Jiayu Feng, Yani Huang, Liyan Huang, Xuemei Zhao, Xinqing Li, Anran Xin, Chengyi Wang, Yuhui Zhang, Jian Zhang
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引用次数: 0

Abstract

Introduction: The prognostic significance of red cell distribution width-SD (RDW-SD) as a promising inflammatory biomarker in individuals with non-ischemic dilated cardiomyopathy (DCM) and varying glycemic status remains unexplored.

Research design and methods: Patients hospitalized for DCM in Fuwai Hospital from 2006 to 2021 were retrospectively included. The primary outcome encompassed all-cause mortality and heart transplantations. The multivariable Cox regression was used to evaluate the association between RDW-SD and outcomes in the overall DCM population, and among patients with normoglycemia (NG), pre-diabetes mellitus (pre-DM) and DM.

Results: Among 1,102 patients with DCM, the median age was 48 years and 23.5% were women. In the overall DCM cohort, the RDW-SD was independently associated with the primary outcome (adjusted HR 1.29, 95% CI 1.15 to 1.45, p<0.001, per SD increase). When stratifying patients with glycemic status, the RDW-SD exhibited an independent association with outcome in patients with DCM with pre-DM and DM, the adjusted HRs were 1.48 (95% CI 1.21 to 1.79, p<0.001) and 1.30 (95% CI 1.06 to 1.60, p=0.011) per SD increase, respectively. However, in patients with DCM and NG, the prognostic value of RDW-SD was insignificant, with an adjusted HR of 1.20 per SD increase (95% CI: 0.97 to 1.48, p=0.101).

Conclusions: RDW-SD was independently associated with the outcome in patients with DCM with pre-DM and DM, suggesting potential individualized therapeutic targets for this subset of patients with DCM.

扩张型心肌病患者不同血糖状况下 RDW-SD 与预后之间的关系。
导言:红细胞分布宽度-SD(RDW-SD)是非缺血性扩张型心肌病(DCM)患者和不同血糖状态患者的一种有希望的炎症生物标志物,其预后意义仍有待探索:回顾性纳入2006年至2021年在阜外医院住院治疗的DCM患者。主要结果包括全因死亡率和心脏移植。采用多变量 Cox 回归法评估 RDW-SD 与整个 DCM 患者以及血糖正常(NG)、糖尿病前期(Pre-DM)和 DM 患者的预后之间的关系:在 1102 名 DCM 患者中,中位年龄为 48 岁,23.5% 为女性。在整个 DCM 队列中,RDW-SD 与主要结局密切相关(调整后 HR 1.29,95% CI 1.15 至 1.45,p 结论:RDW-SD 与主要结局密切相关:RDW-SD与DCM合并DM前期和DM患者的预后有独立相关性,这表明这一DCM患者亚群有可能成为个体化治疗目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
9.30
自引率
2.40%
发文量
123
审稿时长
18 weeks
期刊介绍: BMJ Open Diabetes Research & Care is an open access journal committed to publishing high-quality, basic and clinical research articles regarding type 1 and type 2 diabetes, and associated complications. Only original content will be accepted, and submissions are subject to rigorous peer review to ensure the publication of high-quality — and evidence-based — original research articles.
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