Proteo-metabolomic insights for early dual physical and cognitive impairments: A search for biomarkers of healthy aging based on muscle-brain crosstalk.

IF 8 1区医学 Q1 CELL BIOLOGY

Aging Cell Pub Date : 2024-11-08 DOI:10.1111/acel.14407

Yi-Long Huang, Wei-Ju Chang, Chen-Hua Huang, Chao-Hsiung Lin, Li-Ning Peng, Chih-Ping Chung, Liang-Kung Chen, Wei-Ju Lee

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引用次数: 0

Abstract

We employed an untargeted proteo-metabolomic approach to profile circulating biomarkers in plasma samples from the I-Lan Longitudinal Aging Study, aiming to identify biomarkers and pathways associated with physio-cognitive decline syndrome (PCDS). In 115 propensity score-matched PCDS case-control pairs, pathway analyses implicated dysregulation of fatty acid metabolism and inflammation in PCDS pathogenesis. Sex-specific associations were observed, with disruptions in central carbon metabolism (elevated PKM, MDH1, and GAPDH; decreased MINPP1) and tyrosine metabolism (decreased MIF, DBH; increased thyroxine) characterizing in men. In contrast, perturbations in glutathione and phenylalanine metabolism, including increased ANPEP, GSTP1, and decreased pyroglutamic acid, were identified in women. Results suggest that dysregulated energy and redox homeostasis likely contribute to PCDS development. Notably, ANPEP, PKM, and MIF emerged as potential biomarkers, elucidating the muscle-brain crosstalk framework. Our findings provide insights into potential molecular mechanisms underlying PCDS and the muscle-brain crosstalk, marking progress toward elucidating biomarkers in the journey of healthy aging.

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蛋白质代谢组学对早期身体和认知双重损伤的启示：基于肌肉-大脑串联寻找健康老化的生物标志物。

我们采用了一种非靶向蛋白质代谢组学方法来分析依兰老龄化纵向研究（I-Lan Longitudinal Aging Study）血浆样本中的循环生物标志物，旨在确定与体能认知衰退综合征（PCDS）相关的生物标志物和通路。在 115 对倾向得分匹配的 PCDS 病例对照中，路径分析发现脂肪酸代谢和炎症与 PCDS 的发病机制有关。研究观察到了性别特异性关联，男性的特征是中枢碳代谢紊乱（PKM、MDH1 和 GAPDH 升高；MINPP1 降低）和酪氨酸代谢紊乱（MIF 和 DBH 降低；甲状腺素升高）。相比之下，女性的谷胱甘肽和苯丙氨酸代谢紊乱，包括 ANPEP、GSTP1 增加和焦谷氨酸减少。研究结果表明，能量和氧化还原平衡失调可能是导致 PCDS 发生的原因之一。值得注意的是，ANPEP、PKM 和 MIF 成为潜在的生物标志物，阐明了肌肉-大脑串联框架。我们的研究结果为 PCDS 和肌肉-大脑串联的潜在分子机制提供了见解，标志着在阐明健康老龄化过程中的生物标志物方面取得了进展。

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来源期刊

Aging Cell Biochemistry, Genetics and Molecular Biology-Cell Biology

自引率

2.60%

发文量

212

期刊介绍： Aging Cell is an Open Access journal that focuses on the core aspects of the biology of aging, encompassing the entire spectrum of geroscience. The journal's content is dedicated to publishing research that uncovers the mechanisms behind the aging process and explores the connections between aging and various age-related diseases. This journal aims to provide a comprehensive understanding of the biological underpinnings of aging and its implications for human health. The journal is widely recognized and its content is abstracted and indexed by numerous databases and services, which facilitates its accessibility and impact in the scientific community. These include: Academic Search (EBSCO Publishing) Academic Search Alumni Edition (EBSCO Publishing) Academic Search Premier (EBSCO Publishing) Biological Science Database (ProQuest) CAS: Chemical Abstracts Service (ACS) Embase (Elsevier) InfoTrac (GALE Cengage) Ingenta Select ISI Alerting Services Journal Citation Reports/Science Edition (Clarivate Analytics) MEDLINE/PubMed (NLM) Natural Science Collection (ProQuest) PubMed Dietary Supplement Subset (NLM) Science Citation Index Expanded (Clarivate Analytics) SciTech Premium Collection (ProQuest) Web of Science (Clarivate Analytics) Being indexed in these databases ensures that the research published in Aging Cell is discoverable by researchers, clinicians, and other professionals interested in the field of aging and its associated health issues. This broad coverage helps to disseminate the journal's findings and contributes to the advancement of knowledge in geroscience.